Penetration of ofloxacin into human lung tissue following a single oral dose of 200 milligrams

F. Serour, M. Dan, A. Gorea, A. Yellin, Y. Lieberman, S. Berger

Research output: Contribution to journalArticlepeer-review

Abstract

The penetration of ofloxacin into lung tissue was studied in 10 patients subjected to pulmonary surgery. Samples of blood and lung tissue were obtained 3 to 8 h (mean, 5 h) after oral administration of 200 mg. The mean level in tissue was 2.17 ± 0.5 μg/g, while the mean level in serum was 0.85 ±0.23 μg/ml. The mean lung tissue/serum concentration ratio was 2.55 ± 0.30. The achievable levels of ofloxacin in lung tissue are above the MICs for most pulmonary pathogens.

Original languageEnglish
Pages (from-to)380-381
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume35
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

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