Penetration of ofloxacin into human lung tissue following a single oral dose of 200 milligrams

F. Serour; M. Dan; A. Gorea; A. Yellin; Y. Lieberman; S. Berger

doi:10.1128/AAC.35.2.380

Penetration of ofloxacin into human lung tissue following a single oral dose of 200 milligrams

F. Serour, M. Dan^*, A. Gorea, A. Yellin, Y. Lieberman, S. Berger

^*Corresponding author for this work

Edith Wolfson Medical Center Israel

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The penetration of ofloxacin into lung tissue was studied in 10 patients subjected to pulmonary surgery. Samples of blood and lung tissue were obtained 3 to 8 h (mean, 5 h) after oral administration of 200 mg. The mean level in tissue was 2.17 ± 0.5 μg/g, while the mean level in serum was 0.85 ±0.23 μg/ml. The mean lung tissue/serum concentration ratio was 2.55 ± 0.30. The achievable levels of ofloxacin in lung tissue are above the MICs for most pulmonary pathogens.

Original language	English
Pages (from-to)	380-381
Number of pages	2
Journal	Antimicrobial Agents and Chemotherapy
Volume	35
Issue number	2
DOIs	https://doi.org/10.1128/AAC.35.2.380
State	Published - 1991
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/AAC.35.2.380

Cite this

@article{df9b8aa8e32d4119bba8cd5381e2e2ee,

title = "Penetration of ofloxacin into human lung tissue following a single oral dose of 200 milligrams",

abstract = "The penetration of ofloxacin into lung tissue was studied in 10 patients subjected to pulmonary surgery. Samples of blood and lung tissue were obtained 3 to 8 h (mean, 5 h) after oral administration of 200 mg. The mean level in tissue was 2.17 ± 0.5 μg/g, while the mean level in serum was 0.85 ±0.23 μg/ml. The mean lung tissue/serum concentration ratio was 2.55 ± 0.30. The achievable levels of ofloxacin in lung tissue are above the MICs for most pulmonary pathogens.",

author = "F. Serour and M. Dan and A. Gorea and A. Yellin and Y. Lieberman and S. Berger",

year = "1991",

doi = "10.1128/AAC.35.2.380",

language = "אנגלית",

volume = "35",

pages = "380--381",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "2",

}

TY - JOUR

T1 - Penetration of ofloxacin into human lung tissue following a single oral dose of 200 milligrams

AU - Serour, F.

AU - Dan, M.

AU - Gorea, A.

AU - Yellin, A.

AU - Lieberman, Y.

AU - Berger, S.

PY - 1991

Y1 - 1991

N2 - The penetration of ofloxacin into lung tissue was studied in 10 patients subjected to pulmonary surgery. Samples of blood and lung tissue were obtained 3 to 8 h (mean, 5 h) after oral administration of 200 mg. The mean level in tissue was 2.17 ± 0.5 μg/g, while the mean level in serum was 0.85 ±0.23 μg/ml. The mean lung tissue/serum concentration ratio was 2.55 ± 0.30. The achievable levels of ofloxacin in lung tissue are above the MICs for most pulmonary pathogens.

AB - The penetration of ofloxacin into lung tissue was studied in 10 patients subjected to pulmonary surgery. Samples of blood and lung tissue were obtained 3 to 8 h (mean, 5 h) after oral administration of 200 mg. The mean level in tissue was 2.17 ± 0.5 μg/g, while the mean level in serum was 0.85 ±0.23 μg/ml. The mean lung tissue/serum concentration ratio was 2.55 ± 0.30. The achievable levels of ofloxacin in lung tissue are above the MICs for most pulmonary pathogens.

UR - http://www.scopus.com/inward/record.url?scp=0026035056&partnerID=8YFLogxK

U2 - 10.1128/AAC.35.2.380

DO - 10.1128/AAC.35.2.380

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0026035056

SN - 0066-4804

VL - 35

SP - 380

EP - 381

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 2

ER -

Penetration of ofloxacin into human lung tissue following a single oral dose of 200 milligrams

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this