Penetration of norfloxacin into human prostatic tissue following single-dose oral administration

M. Dan, J. Golomb, A. Gorea, A. Lindner, Stephen A. Berger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Concommitant concentrations of norfloxacin in serum, urine and prostatic tissue were determined in 12 patients following a single oral dose of 400 mg. Tissue levels ranged from 0.3 to 1.73 mg/kg, and therapeutic concentrations were demonstrable for as long as 8 h following dosage. The mean ratio of tissue to serum concentration was 1.01 ±(SE) 0.13.

Original languageEnglish
Pages (from-to)240-242
Number of pages3
JournalChemotherapy
Volume33
Issue number4
DOIs
StatePublished - 1987
Externally publishedYes

Keywords

  • Norfloxacin
  • Pharmacokinetics
  • Prostatitis

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