Penetration of norfloxacin into human prostatic tissue following single-dose oral administration

M. Dan; J. Golomb; A. Gorea; A. Lindner; Stephen A. Berger

doi:10.1159/000238501

Penetration of norfloxacin into human prostatic tissue following single-dose oral administration

M. Dan, J. Golomb, A. Gorea, A. Lindner, Stephen A. Berger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Concommitant concentrations of norfloxacin in serum, urine and prostatic tissue were determined in 12 patients following a single oral dose of 400 mg. Tissue levels ranged from 0.3 to 1.73 mg/kg, and therapeutic concentrations were demonstrable for as long as 8 h following dosage. The mean ratio of tissue to serum concentration was 1.01 ±(SE) 0.13.

Original language	English
Pages (from-to)	240-242
Number of pages	3
Journal	Chemotherapy
Volume	33
Issue number	4
DOIs	https://doi.org/10.1159/000238501
State	Published - 1987
Externally published	Yes

Keywords

Norfloxacin
Pharmacokinetics
Prostatitis

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10.1159/000238501

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title = "Penetration of norfloxacin into human prostatic tissue following single-dose oral administration",

abstract = "Concommitant concentrations of norfloxacin in serum, urine and prostatic tissue were determined in 12 patients following a single oral dose of 400 mg. Tissue levels ranged from 0.3 to 1.73 mg/kg, and therapeutic concentrations were demonstrable for as long as 8 h following dosage. The mean ratio of tissue to serum concentration was 1.01 ±(SE) 0.13.",

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AU - Berger, Stephen A.

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AB - Concommitant concentrations of norfloxacin in serum, urine and prostatic tissue were determined in 12 patients following a single oral dose of 400 mg. Tissue levels ranged from 0.3 to 1.73 mg/kg, and therapeutic concentrations were demonstrable for as long as 8 h following dosage. The mean ratio of tissue to serum concentration was 1.01 ±(SE) 0.13.

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KW - Pharmacokinetics

KW - Prostatitis

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Penetration of norfloxacin into human prostatic tissue following single-dose oral administration

Abstract

Keywords

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