Penetration of clindamycin, cefoxitin, and metronidazole into pelvic peritoneal fluid of women undergoing diagnostic laparoscopy

S. A. Berger; M. Kupferminc; J. B. Lessing; A. Gorea; I. Gull; M. R. Peyser

doi:10.1128/AAC.34.2.376

Penetration of clindamycin, cefoxitin, and metronidazole into pelvic peritoneal fluid of women undergoing diagnostic laparoscopy

S. A. Berger^*
, M. Kupferminc
, J. B. Lessing
, A. Gorea
, I. Gull
, M. R. Peyser

^*Corresponding author for this work

Tel Aviv Sourasky Medical Center

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A single dose of clindamycin, cefoxitin, or metronidazole was administered to each of 30 women. The mean concentration of cefoxitin in pelvic fluid at 1 h exceeded those of the other two drugs (P < 0.007). Cefoxitin concentrations were inferior to those of the other drugs when compared with the published MIC for 90% of Bacteroides fragilis strains.

Original language	English
Pages (from-to)	376-377
Number of pages	2
Journal	Antimicrobial Agents and Chemotherapy
Volume	34
Issue number	2
DOIs	https://doi.org/10.1128/AAC.34.2.376
State	Published - 1990
Externally published	Yes

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10.1128/AAC.34.2.376

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abstract = "A single dose of clindamycin, cefoxitin, or metronidazole was administered to each of 30 women. The mean concentration of cefoxitin in pelvic fluid at 1 h exceeded those of the other two drugs (P < 0.007). Cefoxitin concentrations were inferior to those of the other drugs when compared with the published MIC for 90\% of Bacteroides fragilis strains.",

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AU - Berger, S. A.

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AU - Lessing, J. B.

AU - Gorea, A.

AU - Gull, I.

AU - Peyser, M. R.

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N2 - A single dose of clindamycin, cefoxitin, or metronidazole was administered to each of 30 women. The mean concentration of cefoxitin in pelvic fluid at 1 h exceeded those of the other two drugs (P < 0.007). Cefoxitin concentrations were inferior to those of the other drugs when compared with the published MIC for 90% of Bacteroides fragilis strains.

AB - A single dose of clindamycin, cefoxitin, or metronidazole was administered to each of 30 women. The mean concentration of cefoxitin in pelvic fluid at 1 h exceeded those of the other two drugs (P < 0.007). Cefoxitin concentrations were inferior to those of the other drugs when compared with the published MIC for 90% of Bacteroides fragilis strains.

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Penetration of clindamycin, cefoxitin, and metronidazole into pelvic peritoneal fluid of women undergoing diagnostic laparoscopy

Abstract

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