Pemphigus vulgaris triggered by glibenclamide and cilazapril

Ilan Goldberg, Aushrat Sasson, Andrea Gat, Avigdor Srebrnik, Sarah Brenner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


A case of pemphigus triggered by glibenclamide and cilazapril is described. The suspicion of drug induction was confirmed in a laboratory study in which a pemphigus-like effect was induced by glibenclamide in cultured human skin explants. Withdrawal of the drugs and their replacement by hydrochlorothiazide and metformin resulted in subsidence of the lesions and no appearance of new lesions. The laboratory study carried out to verify the suspicion of drug induced pemphigus and to confirm the diagnosis proved useful in the differential diagnosis in this case.

Original languageEnglish
Pages (from-to)153-155
Number of pages3
JournalActa Dermatovenerologica Croatica
Issue number3
StatePublished - 2005


  • Cilazapril
  • Drug-induced pemphigus
  • Glibenclamide
  • Pemphigus vulgaris


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