Pemphigus vulgaris is characterized by low IgG reactivities to specific self-antigens along with high IgG reactivity to desmoglein 3

Ittai Fattal, Jacob Rimer, Noam Shental, Yair Molad, Armando Gabrielli, Avi Livneh, Ofer Sarig, Ilan Goldberg, Uzi Gafter, Eytan Domany, Irun R. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

Pemphigus vulgaris (PV) is an autoimmune skin disease, which has been characterized by IgG autoantibodies to desmoglein 3. Here we studied the antibody signatures of PV patients compared with healthy subjects and with patients with two other autoimmune diseases with skin manifestations (systemic lupus erythematosus and scleroderma), using an antigen microarray and informatics analysis. We now report a previously unobserved phenomenon - patients with PV, compared with the healthy subjects and the two other diseases, show a significant decrease in IgG autoantibodies to a specific set of self-antigens. This novel finding demonstrates that an autoimmune disease may be associated with a loss of specific, healthy IgG autoantibodies and not only with a gain of specific, pathogenic IgG autoantibodies.

Original languageEnglish
Pages (from-to)374-380
Number of pages7
JournalImmunology
Volume143
Issue number3
DOIs
StatePublished - 2014

Keywords

  • Autoantibodies
  • Pemphigus vulgaris
  • Scleroderma
  • Systemic lupus erythematosus

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