TY - JOUR
T1 - Pemphigus and drugs
T2 - Our experience
AU - Brenner, S.
AU - Goldberg, I.
PY - 2007/8
Y1 - 2007/8
N2 - Various drugs have been implicated in the induction and/or exacerbation of pemphigus. Nevertheless, many cases remain unrecognized. A detailed history - including analgesics, homeopathic drugs, immunizations, and ophthalmic preparations - can disclose the culprit. Elimination of the offending agents may ameliorate the disease and reduce the need for drug treatment. Diagnosis must also take into account the multifactorial nature of the disease, represented by the acronym PEMPHIGUS we proposed: PEsticides, Malignancy, Pharmaceuticals, Hormones, Infectious agents and Immunization, Gastronomy, Ultraviolet radiation, and Stress. A useful tool for identifying culprit drugs in pemphigus patients is the interferon-gamma (INF-γ) release test. Correlation between the results of the test and the clinical picture can lead to the correct diagnosis.
AB - Various drugs have been implicated in the induction and/or exacerbation of pemphigus. Nevertheless, many cases remain unrecognized. A detailed history - including analgesics, homeopathic drugs, immunizations, and ophthalmic preparations - can disclose the culprit. Elimination of the offending agents may ameliorate the disease and reduce the need for drug treatment. Diagnosis must also take into account the multifactorial nature of the disease, represented by the acronym PEMPHIGUS we proposed: PEsticides, Malignancy, Pharmaceuticals, Hormones, Infectious agents and Immunization, Gastronomy, Ultraviolet radiation, and Stress. A useful tool for identifying culprit drugs in pemphigus patients is the interferon-gamma (INF-γ) release test. Correlation between the results of the test and the clinical picture can lead to the correct diagnosis.
KW - Pemphigus, diagnosis
KW - Pemphigus, therapy
KW - Skin
UR - http://www.scopus.com/inward/record.url?scp=36049034030&partnerID=8YFLogxK
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AN - SCOPUS:36049034030
SN - 0392-0488
VL - 142
SP - 409
EP - 414
JO - Giornale Italiano di Dermatologia e Venereologia
JF - Giornale Italiano di Dermatologia e Venereologia
IS - 4
ER -