Abstract
Tubulointerstitial nephritis (TIN) is an immunologically mediated inflammation of renal tubulointerstitium with relative sparing of glomeruli and vessels. Clinical symptoms and laboratory findings of TIN are often unspecific, resulting in a delayed diagnosis, which may lead to a poorer clinical outcome. Renal biopsy is the gold standard of the diagnosis and shows an inflammatory interstitial infiltrate and interstitial edema. Drug-induced TIN accounts for most cases, with antibiotics, proton-pump inhibitors, and NSAIDs as leading etiologic agents. TIN can be diagnosed in association with infections, systemic disease, uveitis, and toxic factors. TIN can be acute and reversible if the offending factor is withdrawn, or may represent a chronic process leading to irreversible renal failure. The role of corticosteroids and other immunosuppressive agents in the treatment of acute TIN is controversial.
Original language | English |
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Title of host publication | Pediatric Nephrology |
Subtitle of host publication | Eighth Edition |
Publisher | Springer International Publishing |
Pages | 1087-1104 |
Number of pages | 18 |
ISBN (Electronic) | 9783030527198 |
ISBN (Print) | 9783030527181 |
DOIs | |
State | Published - 1 Jan 2022 |
Externally published | Yes |
Keywords
- Dress syndrome
- Drug induced disease
- Interstitial inflammation
- Kidney biopsy
- Sjogren syndrome
- Tinu syndrome
- Toxic nephropathy
- Tubulointerstitial fibrosis
- Tubulointerstitial nephritis
- Urine beta 2 microglobulin
- Uveitis