Pediatric clinical use of the ketoconazole/cyclosporin interaction

M. Berkovitch; M. Bitzan; D. Matsui; H. Finkelstein; J. W. balfe; G. Koren

doi:10.1007/BF00856546

Pediatric clinical use of the ketoconazole/cyclosporin interaction

M. Berkovitch, M. Bitzan, D. Matsui, H. Finkelstein, J. W. balfe, G. Koren^*

^*Corresponding author for this work

University of Toronto

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Ketoconazole is known to inhibit the metabolism of cyclosporin through inhibition of cytochrome P-450. This pharmacological interaction was used in an 8-year-old renal transplant patient to successfully achieve therapeutic cyclosporin blood concentrations. The addition of ketoconazole to the cyclosporin regimen should be considered when difficulties are encountered in attaining satisfactory cyclosporin levels.

Original language	English
Pages (from-to)	492-493
Number of pages	2
Journal	Pediatric Nephrology
Volume	8
Issue number	4
DOIs	https://doi.org/10.1007/BF00856546
State	Published - Aug 1994
Externally published	Yes

Keywords

Cyclosporin
Ketoconazole
Renal transplant

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10.1007/BF00856546

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abstract = "Ketoconazole is known to inhibit the metabolism of cyclosporin through inhibition of cytochrome P-450. This pharmacological interaction was used in an 8-year-old renal transplant patient to successfully achieve therapeutic cyclosporin blood concentrations. The addition of ketoconazole to the cyclosporin regimen should be considered when difficulties are encountered in attaining satisfactory cyclosporin levels.",

keywords = "Cyclosporin, Ketoconazole, Renal transplant",

author = "M. Berkovitch and M. Bitzan and D. Matsui and H. Finkelstein and balfe, {J. W.} and G. Koren",

year = "1994",

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AU - Finkelstein, H.

AU - balfe, J. W.

AU - Koren, G.

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AB - Ketoconazole is known to inhibit the metabolism of cyclosporin through inhibition of cytochrome P-450. This pharmacological interaction was used in an 8-year-old renal transplant patient to successfully achieve therapeutic cyclosporin blood concentrations. The addition of ketoconazole to the cyclosporin regimen should be considered when difficulties are encountered in attaining satisfactory cyclosporin levels.

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KW - Ketoconazole

KW - Renal transplant

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Pediatric clinical use of the ketoconazole/cyclosporin interaction

Abstract

Keywords

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