PCI complexes: Pretty complex interactions in diverse signaling pathways

Tae Houn Kim, Kay Hofmann, Albrecht G. Von Arnim, Daniel A. Chamovitz*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Three protein complexes (the proteasome regulatory lid, the COP9 signalosome and eukaryotic translation initiation factor 3) contain protein subunits with a well defined protein domain, the PCI domain. At least two (the COP9 signalosome and the lid) appear to share a common evolutionary origin. Recent advances in our understanding of the structure and function of the three complexes point to intriguing and unanticipated connections between the cellular functions performed by these three protein assemblies, especially between translation initiation and proteolytic protein degradation.

Original languageEnglish
Pages (from-to)379-386
Number of pages8
JournalTrends in Plant Science
Issue number8
StatePublished - 2001


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