@article{71c2a9709ec04b3a95b72963a24de019,
title = "Pax6 regulation of Sox9 in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature development",
abstract = "The synchronized differentiation of neuronal and vascular tissues is crucial for normal organ development and function, although there is limited information about the mechanisms regulating the coordinated development of these tissues. The choroid vasculature of the eye serves as the main blood supply to the metabolically active photoreceptors, and develops together with the retinal pigmented epithelium (RPE). Here, we describe a novel regulatory relationship between the RPE transcription factors Pax6 and Sox9 that controls the timing of RPE differentiation and the adjacent choroid maturation. We used a novel machine learning algorithm tool to analyze high resolution imaging of the choroid in Pax6 and Sox9 conditional mutant mice. Additional unbiased transcriptomic analyses in mutant mice and RPE cells generated from human embryonic stem cells, as well as chromatin immunoprecipitation and high-throughput analyses, revealed secreted factors that are regulated by Pax6 and Sox9. These factors might be involved in choroid development and in the pathogenesis of the common blinding disease: age-related macular degeneration (AMD).",
keywords = "Age-related macular degeneration, Choroid vasculature, Pax6, Retinal pigmented epithelium, Sox9",
author = "Yamit Cohen-Tayar and Hadar Cohen and Yulia Mitiagin and Zohar Abravanel and Carmit Levy and Masha Idelson and Benjamin Reubinoff and Shalev Itzkovitz and Shaul Raviv and Kaestner, {Klaus H.} and Pablo Blinder and Ran Elkon and Ruth Ashery-Padan",
note = "Publisher Copyright: {\textcopyright} 2018. Published by The Company of Biologists Ltd.",
year = "2018",
month = aug,
doi = "10.1242/dev.163691",
language = "אנגלית",
volume = "145",
journal = "Development (Cambridge)",
issn = "0950-1991",
publisher = "Company of Biologists Ltd",
number = "15",
}