Patterns of lactate dehydrogenase isoenzymes in serum of patients with acute pulmonary edema

Z. Rotenberg, I. Weinberger, E. Davidson, J. Fuchs, O. Sperling, J. Agmon

Research output: Contribution to journalArticlepeer-review

Abstract

Total lactate dehydrogenase (LD; EC 1.1.1.27) activity in serum and proportions of LD isoenzymes were quantified on admission and discharge in 170 selected (from 240) patients with acute pulmonary edema (APE). The patients were divided into group A, 75 patients with normal LD values (< 225 U/L); and groups B-E, with increased LD activity in serum: group B, 40 patients with increase in the proportion of LD-3 (> 38%); group C, 12 patients with increased LD-5; group D, 36 patients with an isomorphic pattern of LD isoenzymes; and group E, seven patients with LD-1/LD-2 > 0.76. Nine patients in group C (75%) had also signs of right-sided congestive heart failure, 30 in group D (83%) had hypotension on admission, and six in group E (86%) had signs of recent myocardial infarction. Evidently, half of patients with APE may show increased total LD activity in serum at the time of admission. LD isoenzyme proportions should be determined in such patients, because there is no one typical pattern of LD isoenzymes and some LD isoenzyme patterns may be associated with specific clinical situations.

Original languageEnglish
Pages (from-to)1882-1884
Number of pages3
JournalClinical Chemistry
Volume34
Issue number9
DOIs
StatePublished - 1988
Externally publishedYes

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