TY - JOUR
T1 - Patients with Turner's syndrome may have an inherent endometrial abnormality affecting receptivity in oocyte donation
AU - Yaron, Y.
AU - Ochshorn, Y.
AU - Amit, A.
AU - Yovel, I.
AU - Kogosowski, A.
AU - Lessing, J. B.
PY - 1996
Y1 - 1996
N2 - Objective: To evaluate whether endometrial receptivity is compromised in patients with premature ovarian failure (POF) due to Turner's syndrome who undergo oocyte donation. Design: Retrospective analysis. Setting: In vitro fertilization-ET units, anonymous oocyte donation program. Patients: The study included 53 patients with POF who underwent oocyte donation. These included 7 patients with Turner's syndrome (45,X) who underwent 22 ET cycles, 15 women with Turner variants (mosaics, deletions, or isochromosomes) who underwent 36 ET cycles, and 31 other patients with POF and a normal karyotype who underwent 69 oocyte donation cycles. Intervention: All patients on standby for donation were treated with E2 valerate 6 mg/d until oocytes became available; then P 100 mg/d was added. Oocyte donors were healthy women <34 years who underwent IVF themselves. Main Outcome Measures: Clinical pregnancy rates (PRs), biochemical pregnancies, early abortions, and delivery rates were evaluated. Results: Turner's syndrome patients had a significantly higher rate of biochemical pregnancies (22.7% versus 4.3%), a lower clinical PR (22.7% versus 33.3%), a significantly higher rate of early abortions (60% versus 8.7%), and a significantly lower rate of deliveries per pregnancy (20.0% versus 73.1%) compared with non-Turner patients. Conclusions: Patients with a complete or partial deficiency of an X chromosome have reduced PRs and an increase in early implantation failure after oocyte donation. This may indicate an inherent endometrial abnormality, possibly associated with a deficiency of X-linked genes regulating endometrial receptivity.
AB - Objective: To evaluate whether endometrial receptivity is compromised in patients with premature ovarian failure (POF) due to Turner's syndrome who undergo oocyte donation. Design: Retrospective analysis. Setting: In vitro fertilization-ET units, anonymous oocyte donation program. Patients: The study included 53 patients with POF who underwent oocyte donation. These included 7 patients with Turner's syndrome (45,X) who underwent 22 ET cycles, 15 women with Turner variants (mosaics, deletions, or isochromosomes) who underwent 36 ET cycles, and 31 other patients with POF and a normal karyotype who underwent 69 oocyte donation cycles. Intervention: All patients on standby for donation were treated with E2 valerate 6 mg/d until oocytes became available; then P 100 mg/d was added. Oocyte donors were healthy women <34 years who underwent IVF themselves. Main Outcome Measures: Clinical pregnancy rates (PRs), biochemical pregnancies, early abortions, and delivery rates were evaluated. Results: Turner's syndrome patients had a significantly higher rate of biochemical pregnancies (22.7% versus 4.3%), a lower clinical PR (22.7% versus 33.3%), a significantly higher rate of early abortions (60% versus 8.7%), and a significantly lower rate of deliveries per pregnancy (20.0% versus 73.1%) compared with non-Turner patients. Conclusions: Patients with a complete or partial deficiency of an X chromosome have reduced PRs and an increase in early implantation failure after oocyte donation. This may indicate an inherent endometrial abnormality, possibly associated with a deficiency of X-linked genes regulating endometrial receptivity.
KW - IVF- ET
KW - Premature ovarian failure
KW - Turner's syndrome
KW - endometrial receptivity
UR - http://www.scopus.com/inward/record.url?scp=0029890548&partnerID=8YFLogxK
U2 - 10.1016/s0015-0282(16)58350-2
DO - 10.1016/s0015-0282(16)58350-2
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AN - SCOPUS:0029890548
SN - 0015-0282
VL - 65
SP - 1249
EP - 1252
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 6
ER -