This chapter reviews the up-to-date literature in regard to patient-specific modeling of the human cornea. First, the relevant anatomical, morphological and physiological aspects are summarized. Then, examples of non-patient-specific seldom are addressed before existing patient-specific models are discussed. Finally, an overview is presented, of the development of a patient-specific model that can aid the clinician to prognose response to different intraocular pressure controlling medications. This feature can be very useful in cases of keratoconus—a disease of the cornea which involves changes to the corneal microstructure as well as to its macrostructure, gradually causing a conic-like corneal shape that distorts vision.