Patient-specific modeling for the assessment of circulatory adaptation in fetal growth restriction

O. Luria*, J. Bar, M. Kovo, J. Shalev, O. Barnea

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Fetal growth restriction (FGR) is one of the major contributors to adverse perinatal outcome. However, the diagnostic tools currently used for estimating the fetal hemodynamic status are still limited. In this study we developed a methodology for estimating fetal hemodynamic parameters. The method is based on a mathematical model of the fetal circulation, an optimization algorithm and measurements of power-Doppler ultrasound. The model estimates parameters of the fetal circulation that are not possible for direct measurement. The method was tested on a cohort of 20 normal and 22 growth-restricted fetuses. In each fetus, power-Doppler velocity waveforms were measured in large number of sites of the fetal circulation. Three-dimensional volume-flow measurements were performed in the placenta to evaluate its resistance to blood flow. Model predictions indicated significant changes in the circulation of FGR fetuses compared to normal fetuses. In the FGR group, the model predicted significant reduction in fetal cardiac output and decreased cardiac output distribution towards the placenta. In FGR fetuses that showed adverse outcome, the model indicated significant increase in cardiac output distribution towards the brain and in the degree of blood shunted by the ductus venosus, indicating severe brainsparing state in these fetuses. We conclude that patientspecific modeling may be useful in personalizing and optimizing the treatment options in pregnancies complicated by fetal growth-restriction.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Number of pages4
StatePublished - 2013
EventWorld Congress on Medical Physics and Biomedical Engineering - Beijing, China
Duration: 26 May 201231 May 2012

Publication series

NameIFMBE Proceedings
Volume39 IFMBE
ISSN (Print)1680-0737


ConferenceWorld Congress on Medical Physics and Biomedical Engineering


  • Brain-sparing effect
  • Fetal growth restriction
  • Mathematical model
  • Patient-specific modeling
  • Placental resistance to blood flow
  • Power Doppler ultrasonography


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