TY - JOUR
T1 - Patient-specific FE analyses of metatarsal bones with inhomogeneous isotropic material properties
AU - Trabelsi, Nir
AU - Milgrom, Charles
AU - Yosibash, Zohar
N1 - Funding Information:
NR and ZY gratefully acknowledge the generous support of the Technical University of Munich – Institute for Advanced Study, funded by the German Excellence Initiative.
Funding Information:
CM and ZY gratefully acknowledge the partial support of this work by the Chief Scientist Office of the Ministry of Health , Israel under Grant No. 293 3-00000-7375 .
Funding Information:
Funding: Partial support was provided by: IAS-TUM, Germany, Chief Scientist Office of the Ministry of Health, Israel, Bonfix LTD, Israel.
PY - 2014/1
Y1 - 2014/1
N2 - The mechanical response of human metatarsal bones is of importance in both research and clinical practice, especially when associated with the correction of Hallux Valgus. Verified and validated patient-specific finite-element analysis (FEA) based on CT scans developed for human femurs are extended here to the first and second metatarsal bones.Two fresh-frozen metatarsal #1 and five metatarsal #2 bones from three donors were loaded in-vitro at three different angles. Holes typical to Hallux Valgus correction were then drilled in the bones, which were reloaded until fracture. In parallel, high-order FE models of the bones were created from CT-scans that mimic the experimental setting. We validated the FE results by comparison to experimental observations.Excellent agreement was obtained with R2=0.97 and slope of the regression line close to 1. We also compared the FE predicted fracture load and location for the second metatarsal bones with these measured in the experiment, demonstrating an excellent prediction within 10% difference.After validation of the FE predictions, they were used to investigate the effect of drilled hole position, dimension and the insertion of a metallic device on the mechanical response so to optimize the outcome of the Hallux Valgus correction.This study further substantiates the potential use of FEA in clinical practice.
AB - The mechanical response of human metatarsal bones is of importance in both research and clinical practice, especially when associated with the correction of Hallux Valgus. Verified and validated patient-specific finite-element analysis (FEA) based on CT scans developed for human femurs are extended here to the first and second metatarsal bones.Two fresh-frozen metatarsal #1 and five metatarsal #2 bones from three donors were loaded in-vitro at three different angles. Holes typical to Hallux Valgus correction were then drilled in the bones, which were reloaded until fracture. In parallel, high-order FE models of the bones were created from CT-scans that mimic the experimental setting. We validated the FE results by comparison to experimental observations.Excellent agreement was obtained with R2=0.97 and slope of the regression line close to 1. We also compared the FE predicted fracture load and location for the second metatarsal bones with these measured in the experiment, demonstrating an excellent prediction within 10% difference.After validation of the FE predictions, they were used to investigate the effect of drilled hole position, dimension and the insertion of a metallic device on the mechanical response so to optimize the outcome of the Hallux Valgus correction.This study further substantiates the potential use of FEA in clinical practice.
KW - Bone biomechanics
KW - Computed tomography (CT)
KW - Finite element analysis
KW - Metatarsal
KW - P-FEM
UR - http://www.scopus.com/inward/record.url?scp=84884928240&partnerID=8YFLogxK
U2 - 10.1016/j.jmbbm.2013.08.030
DO - 10.1016/j.jmbbm.2013.08.030
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C2 - 24095899
AN - SCOPUS:84884928240
SN - 1751-6161
VL - 29
SP - 177
EP - 189
JO - Journal of the Mechanical Behavior of Biomedical Materials
JF - Journal of the Mechanical Behavior of Biomedical Materials
ER -