Patient-based abdominal aortic aneurysm rupture risk prediction with fluid structure interaction modeling

Michalis Xenos, Suraj H. Rambhia, Yared Alemu, Shmuel Einav, Nicos Labropoulos, Apostolos Tassiopoulos, John J. Ricotta, Danny Bluestein

Research output: Contribution to journalArticlepeer-review

Abstract

Elective repair of abdominal aortic aneurysm (AAA) is warranted when the risk of rupture exceeds that of surgery, and is mostly based on the AAA size as a crude rupture predictor. A methodology based on biomechanical considerations for a reliable patient-specific prediction of AAA risk of rupture is presented. Fluid-structure interaction (FSI) simulations conducted in models reconstructed from CT scans of patients who had contained ruptured AAA (rAAA) predicted the rupture location based on mapping of the stresses developing within the aneurysmal wall, additionally showing that a smaller rAAA presented a higher rupture risk. By providing refined means to estimate the risk of rupture, the methodology may have a major impact on diagnostics and treatment of AAA patients.

Original languageEnglish
Pages (from-to)3323-3337
Number of pages15
JournalAnnals of Biomedical Engineering
Volume38
Issue number11
DOIs
StatePublished - Nov 2010
Externally publishedYes

Keywords

  • Aneurysmal strength
  • Fluid-structure interaction
  • Reconstruction of patient based geometry
  • Rupture potential index
  • Ruptured abdominal aortic aneurysm

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