Pathways of polyunsaturated fatty acid utilization: Implications for brain function in neuropsychiatric health and disease

Joanne J. Liu, Pnina Green, J. John Mann, Stanley I. Rapoport, M. Elizabeth Sublette

Research output: Contribution to journalReview articlepeer-review

Abstract

Essential polyunsaturated fatty acids (PUFAs) have profound effects on brain development and function. Abnormalities of PUFA status have been implicated in neuropsychiatric diseases such as major depression, bipolar disorder, schizophrenia, Alzheimer's disease, and attention deficit hyperactivity disorder. Pathophysiologic mechanisms could involve not only suboptimal PUFA intake, but also metabolic and genetic abnormalities, defective hepatic metabolism, and problems with diffusion and transport. This article provides an overview of physiologic factors regulating PUFA utilization, highlighting their relevance to neuropsychiatric disease.

Original languageEnglish
Pages (from-to)220-246
Number of pages27
JournalBrain Research
Volume1597
DOIs
StatePublished - 9 Feb 2015
Externally publishedYes

Keywords

  • Bipolar disorder
  • Brain
  • Depression
  • Lipid metabolism
  • Polyunsaturated fatty acids
  • Schizophrenia

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