@article{fadf3bdac91a490eba0b2013d7ea7f24,
title = "'Pathway drug cocktail': Targeting Ras signaling based on structural pathways",
abstract = "Tumors bearing Ras mutations are notoriously difficult to treat. Drug combinations targeting the Ras protein or its pathway have also not met with success. 'Pathway drug cocktails', which are combinations aiming at parallel pathways, appear more promising; however, to be usefully exploited, a repertoire of classified pathway combinations is desirable. This challenge would be facilitated by the availability of the structural network of signaling pathways. When integrated with functional and systems level clinical data, they can be powerful in advancing novel therapeutic platforms. Based on structural knowledge, drug cocktails may tear into multiple cellular processes that drive tumorigenesis, and help in deciphering the interrelationship between Ras mutations and the rewired Ras network. The pathway drug cocktail paradigm can be applied to other signaling protein targets.",
keywords = "Cancer, Classification, Drug discovery, Oncogenic mutations, Parallel pathways, Structures",
author = "Ruth Nussinov and Tsai, {Chung Jung} and Carla Mattos",
note = "Funding Information: We would like to thank Christian W. Johnson for making Figures 3 and 4 . This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health (NIH), under contract number HHSN261200800001E. This research was supported (in part) by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research (R.N.) and by the extramural program under grant number R56 CA096867 (C.M.). ",
year = "2013",
month = nov,
doi = "10.1016/j.molmed.2013.07.009",
language = "אנגלית",
volume = "19",
pages = "695--704",
journal = "Trends in Molecular Medicine",
issn = "1471-4914",
publisher = "Elsevier Ltd.",
number = "11",
}
