Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ

M. Hernandez-Valladares; J. Naessens; A. J. Musoke; K. Sekikawa; P. Rihet; O. K. ole-MoiYoi; P. Busher; F. A. Iraqi

doi:10.1016/j.exppara.2006.04.003

Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ

M. Hernandez-Valladares^*, J. Naessens, A. J. Musoke, K. Sekikawa, P. Rihet, O. K. ole-MoiYoi, P. Busher, F. A. Iraqi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival rate and several pathological features in C57BL/6JTnf^-/- and C57BL/6JTnf^+/+ mice after infection with Plasmodium chabaudi adami 408XZ. Compared to the C57BL/6JTnf^+/+ mice, C57BL/6JTnf^-/- mice showed increased parasitemia and decreased survival rate, whereas blood glucose, blood lactate and body weight were not significantly different. However, C57BL/6JTnf^-/- mice suffered significantly more from severe anemia and hypothermia than C57BL/6JTnf^+/+ mice. These results suggest that Tnf is an important mediator of parasite control, but not of anemia development. We hypothesize that the high mortality observed in the Tnf knock-out mice is due to increased anemia and pathology as a direct result of increased levels of parasitemia.

Original language	English
Pages (from-to)	271-278
Number of pages	8
Journal	Experimental Parasitology
Volume	114
Issue number	4
DOIs	https://doi.org/10.1016/j.exppara.2006.04.003
State	Published - Dec 2006
Externally published	Yes

Keywords

ANOVA, analysis of variance
Anemia
C57BL/6J
Hb, hemoglobin
Hypothermia
Murine malaria
Parasitemia
Plasmodium chabaudi adami 408XZ
RBC, red blood cells
SEM, standard error of the mean
Survival rate
Tnf
pi, postinfection

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.exppara.2006.04.003

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@article{c6f7e8a17faf414c9dc537b258cfdfe0,

title = "Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ",

abstract = "Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival rate and several pathological features in C57BL/6JTnf-/- and C57BL/6JTnf+/+ mice after infection with Plasmodium chabaudi adami 408XZ. Compared to the C57BL/6JTnf+/+ mice, C57BL/6JTnf-/- mice showed increased parasitemia and decreased survival rate, whereas blood glucose, blood lactate and body weight were not significantly different. However, C57BL/6JTnf-/- mice suffered significantly more from severe anemia and hypothermia than C57BL/6JTnf+/+ mice. These results suggest that Tnf is an important mediator of parasite control, but not of anemia development. We hypothesize that the high mortality observed in the Tnf knock-out mice is due to increased anemia and pathology as a direct result of increased levels of parasitemia.",

keywords = "ANOVA, analysis of variance, Anemia, C57BL/6J, Hb, hemoglobin, Hypothermia, Murine malaria, Parasitemia, Plasmodium chabaudi adami 408XZ, RBC, red blood cells, SEM, standard error of the mean, Survival rate, Tnf, pi, postinfection",

author = "M. Hernandez-Valladares and J. Naessens and Musoke, {A. J.} and K. Sekikawa and P. Rihet and ole-MoiYoi, {O. K.} and P. Busher and Iraqi, {F. A.}",

note = "Funding Information: This work was supported by research grants from the French Ministry of Research (PAL + Program) and the Institute of Molecular and Cell Biology of Africa (IMCB-A). It had logistical and technical support from the International Livestock Research Institute (ILRI). We thank Moses Ogugo, Nemuel Nyamweya, Thomas Njoroge, Stephen Njuguna, Gideon Ndambuki, Joseph Ntale, Dismus Lugo, and Jane Ikanyi from ILRI for their excellent technical assistance. We also thank Dr. S. J. Foote, The Walter, and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia, for the parasite strain. Maria Hernandez-Valladares was supported by IMCB-A and the International Centre of Insect Physiology and Ecology (ICIPE).",

year = "2006",

month = dec,

doi = "10.1016/j.exppara.2006.04.003",

language = "אנגלית",

volume = "114",

pages = "271--278",

journal = "Experimental Parasitology",

issn = "0014-4894",

publisher = "Academic Press Inc.",

number = "4",

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TY - JOUR

T1 - Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ

AU - Hernandez-Valladares, M.

AU - Naessens, J.

AU - Musoke, A. J.

AU - Sekikawa, K.

AU - Rihet, P.

AU - ole-MoiYoi, O. K.

AU - Busher, P.

AU - Iraqi, F. A.

N1 - Funding Information: This work was supported by research grants from the French Ministry of Research (PAL + Program) and the Institute of Molecular and Cell Biology of Africa (IMCB-A). It had logistical and technical support from the International Livestock Research Institute (ILRI). We thank Moses Ogugo, Nemuel Nyamweya, Thomas Njoroge, Stephen Njuguna, Gideon Ndambuki, Joseph Ntale, Dismus Lugo, and Jane Ikanyi from ILRI for their excellent technical assistance. We also thank Dr. S. J. Foote, The Walter, and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia, for the parasite strain. Maria Hernandez-Valladares was supported by IMCB-A and the International Centre of Insect Physiology and Ecology (ICIPE).

PY - 2006/12

Y1 - 2006/12

N2 - Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival rate and several pathological features in C57BL/6JTnf-/- and C57BL/6JTnf+/+ mice after infection with Plasmodium chabaudi adami 408XZ. Compared to the C57BL/6JTnf+/+ mice, C57BL/6JTnf-/- mice showed increased parasitemia and decreased survival rate, whereas blood glucose, blood lactate and body weight were not significantly different. However, C57BL/6JTnf-/- mice suffered significantly more from severe anemia and hypothermia than C57BL/6JTnf+/+ mice. These results suggest that Tnf is an important mediator of parasite control, but not of anemia development. We hypothesize that the high mortality observed in the Tnf knock-out mice is due to increased anemia and pathology as a direct result of increased levels of parasitemia.

AB - Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival rate and several pathological features in C57BL/6JTnf-/- and C57BL/6JTnf+/+ mice after infection with Plasmodium chabaudi adami 408XZ. Compared to the C57BL/6JTnf+/+ mice, C57BL/6JTnf-/- mice showed increased parasitemia and decreased survival rate, whereas blood glucose, blood lactate and body weight were not significantly different. However, C57BL/6JTnf-/- mice suffered significantly more from severe anemia and hypothermia than C57BL/6JTnf+/+ mice. These results suggest that Tnf is an important mediator of parasite control, but not of anemia development. We hypothesize that the high mortality observed in the Tnf knock-out mice is due to increased anemia and pathology as a direct result of increased levels of parasitemia.

KW - ANOVA, analysis of variance

KW - Anemia

KW - C57BL/6J

KW - Hb, hemoglobin

KW - Hypothermia

KW - Murine malaria

KW - Parasitemia

KW - Plasmodium chabaudi adami 408XZ

KW - RBC, red blood cells

KW - SEM, standard error of the mean

KW - Survival rate

KW - Tnf

KW - pi, postinfection

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U2 - 10.1016/j.exppara.2006.04.003

DO - 10.1016/j.exppara.2006.04.003

M3 - מאמר

AN - SCOPUS:33750325265

VL - 114

SP - 271

EP - 278

JO - Experimental Parasitology

JF - Experimental Parasitology

SN - 0014-4894

IS - 4

ER -

Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ

Abstract

Keywords

UN SDGs

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