Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ

M. Hernandez-Valladares*, J. Naessens, A. J. Musoke, K. Sekikawa, P. Rihet, O. K. ole-MoiYoi, P. Busher, F. A. Iraqi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival rate and several pathological features in C57BL/6JTnf-/- and C57BL/6JTnf+/+ mice after infection with Plasmodium chabaudi adami 408XZ. Compared to the C57BL/6JTnf+/+ mice, C57BL/6JTnf-/- mice showed increased parasitemia and decreased survival rate, whereas blood glucose, blood lactate and body weight were not significantly different. However, C57BL/6JTnf-/- mice suffered significantly more from severe anemia and hypothermia than C57BL/6JTnf+/+ mice. These results suggest that Tnf is an important mediator of parasite control, but not of anemia development. We hypothesize that the high mortality observed in the Tnf knock-out mice is due to increased anemia and pathology as a direct result of increased levels of parasitemia.

Original languageEnglish
Pages (from-to)271-278
Number of pages8
JournalExperimental Parasitology
Issue number4
StatePublished - Dec 2006
Externally publishedYes


  • ANOVA, analysis of variance
  • Anemia
  • C57BL/6J
  • Hb, hemoglobin
  • Hypothermia
  • Murine malaria
  • Parasitemia
  • Plasmodium chabaudi adami 408XZ
  • RBC, red blood cells
  • SEM, standard error of the mean
  • Survival rate
  • Tnf
  • pi, postinfection


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