Pathologic features of the placenta in women with severe pregnancy complications and thrombophilia

Ariel Many*, Letizia Schreiber, Serena Rosner, Joseph B. Lessing, Amiram Eldor, Michael J. Kupferminc

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To compare placental pathology between women with and without thrombophilia who had severe preeclampsia, intrauterine growth retardation, severe abruptio placentae, or stillbirth. METHODS: After delivery, 68 women with singleton pregnancies with one of the above complications were evaluated for an inherited thrombophilia: factor V Leiden, methylenetetrahydrofolate reductase and prothrombin gene mutation, and deficiencies of protein S, protein C, and antithrombin III. Thirty-two women were thrombophilic (group A), and 36 women were not (group B). There was no difference in maternal age, parity, and type of pregnancy complication. A single pathologist examined each placenta. RESULTS: The gestational age at delivery, birth weight, and placental weight were significantly lower in group A. Three parameters showed significant differences between the groups: thrombophilic women had a higher number of villous infarcts (P < .01), more multiple infarcts (P < .05), and a higher incidence of placentas with fibrinoid necrosis of decidual vessels (P < .05). CONCLUSION: Placentas of women with severe complications and thrombophilia have an increased rate of vascular lesions.

Original languageEnglish
Pages (from-to)1041-1044
Number of pages4
JournalObstetrics and Gynecology
Issue number6
StatePublished - 2001


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