Pathogenic role of anti-endothelial cell antibodies in autoimmune rheumatic diseases

D. S. Domiciano, J. F. Carvalho, Yehuda Shoenfeld*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Anti-endothelial cells antibodies have been detected in numerous autoimmune and inflammatory diseases, including systemic lupus erythematous, rheumatoid arthritis, vasculitis and sarcoidosis. Anti-endothelial cells antibodies bind to endothelial cell antigens and induce endothelial damage. Their effects on the endothelial cell have been considered responsible, at least in part, by the vascular injury which occurs in these pathological conditions.

Original languageEnglish
Pages (from-to)1233-1238
Number of pages6
JournalLupus
Volume18
Issue number13
DOIs
StatePublished - 2009

Keywords

  • Anti-endothelial
  • Antibodies
  • Autoimmune diseases
  • Endothelial cells
  • Pathogenesis

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