Pathogenic Mechanisms and Clinical Relevance of Autoantibodies

Ricard Cervera; Manel Juan; Yehuda Shoenfeld

doi:10.1016/B978-0-444-56378-1.00006-X

Pathogenic Mechanisms and Clinical Relevance of Autoantibodies

Ricard Cervera, Manel Juan, Yehuda Shoenfeld

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

A direct pathogenic effect of many antibodies has been proven, although in other cases the mechanisms whereby they cause damage are not clear. Some well-defined mechanisms of autoantibody-mediated tissue/cell damage include binding to surface molecules (on cell membrane and subsequent cell death or change of molecular function without cytolysis), immune complex-mediated tissue damage, interaction and modification of intracellular antigens, and binding to extracellular molecules.

Original language	English
Title of host publication	Autoantibodies, Third Edition
Publisher	Elsevier
Pages	51-57
Number of pages	7
ISBN (Electronic)	9780444563781
ISBN (Print)	9780444593771
DOIs	https://doi.org/10.1016/B978-0-444-56378-1.00006-X
State	Published - 1 Jan 2014
Externally published	Yes

Keywords

antibody-dependent cell-mediated cell death
complement-mediated cell death
cross-reaction
cytolysis
cytotoxicity
immune complex-mediated damage
mononuclear phagocyte system
phagocytosis
translocation

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10.1016/B978-0-444-56378-1.00006-X

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AB - A direct pathogenic effect of many antibodies has been proven, although in other cases the mechanisms whereby they cause damage are not clear. Some well-defined mechanisms of autoantibody-mediated tissue/cell damage include binding to surface molecules (on cell membrane and subsequent cell death or change of molecular function without cytolysis), immune complex-mediated tissue damage, interaction and modification of intracellular antigens, and binding to extracellular molecules.

KW - antibody-dependent cell-mediated cell death

KW - complement-mediated cell death

KW - cross-reaction

KW - cytolysis

KW - cytotoxicity

KW - immune complex-mediated damage

KW - mononuclear phagocyte system

KW - phagocytosis

KW - translocation

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BT - Autoantibodies, Third Edition

PB - Elsevier

ER -

Pathogenic Mechanisms and Clinical Relevance of Autoantibodies

Abstract

Keywords

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