TY - JOUR
T1 - Pathogenesis of the antiphospholipid syndrome. The infectious agents theory
AU - Shoenfeld, Y.
AU - Blank, M.
AU - Sherer, Y.
PY - 2004
Y1 - 2004
N2 - The antiphospholipid syndrome (APS) is characterized by the presence of pathogenic autoantibodies against β2-glycoprotein-I (β2GPI). Studies of experimental APS models emphasized that molecular mimicry between β2GPI related synthetic peptides and structures within bacteria, viruses, tetanus toxoid, and cytomegalovirus as a cause for experimental APS. In this review we discuss the association of antiphospholipid antibodies with infectious agents, molecular mimicry as a proposed cause for development of APS, and the contribution of database to this topic.
AB - The antiphospholipid syndrome (APS) is characterized by the presence of pathogenic autoantibodies against β2-glycoprotein-I (β2GPI). Studies of experimental APS models emphasized that molecular mimicry between β2GPI related synthetic peptides and structures within bacteria, viruses, tetanus toxoid, and cytomegalovirus as a cause for experimental APS. In this review we discuss the association of antiphospholipid antibodies with infectious agents, molecular mimicry as a proposed cause for development of APS, and the contribution of database to this topic.
KW - Antiphospholipid syndrome
KW - Infection
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=7044263135&partnerID=8YFLogxK
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AN - SCOPUS:7044263135
SN - 1129-8758
VL - 5
SP - 142
EP - 145
JO - Progressi in Reumatologia
JF - Progressi in Reumatologia
IS - 2
ER -
