Pathogenesis of hypocalcemia in neonatal polycythemia

P. Merlob*, J. Amir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Hypocalcemia (HC) is a frequent complication of neonatal polycythemia (NP): 9.93% in the present study. Its pathogenesis is not clear. We suggest that one of the main pathogenetic explanation of HC in NP is the high level of phosphate significantly different (p < 0.01) than serum phosphate of normal normocalcemic non-polycythemic newborns. The intense postnatal erythrocyte breakdown will increase the serum level of phosphate. This hyperphosphatemia will decrease calcium ion concentration by their combination and bone deposition, a process allowed by inadequate postnatal parathyroid gland response.

Original languageEnglish
Pages (from-to)49-50
Number of pages2
JournalMedical Hypotheses
Volume30
Issue number1
DOIs
StatePublished - Sep 1989
Externally publishedYes

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