Pathogen detection using short-RNA deep sequencing subtraction and assembly

Ofer Isakov, Shira Modai, Noam Shomron

Research output: Contribution to journalArticlepeer-review


Motivation: Early and accurate detection of human pathogen infection is critical for treatment and therapeutics. Here we describe pathogen identification using short RNA subtraction and assembly (SRSA), a detection method that overcomes the requirement of prior knowledge and culturing of pathogens, by using degraded small RNA and deep sequencing technology. We prove our approach's efficiency through identification of a combined viral and bacterial infection in human cells.

Original languageEnglish
Article numberbtr349
Pages (from-to)2027-2030
Number of pages4
Issue number15
StatePublished - Aug 2011


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