TY - JOUR
T1 - Paternal age predicts live birth in women above 40 years of age undergoing in-vitro fertilization (IVF)
AU - Shrem, Guy
AU - Alasmari, Nouf M.
AU - Balayla, Jacques
AU - Volodarsky-Perel, Alexander
AU - Son, Weon Young
AU - Dahan, Michael H.
N1 - Publisher Copyright:
© 2021 The Authors.
PY - 2021/4/15
Y1 - 2021/4/15
N2 - Purpose: To determine which factors predict pregnancy outcome in women aged 40 years and above who underwent in-vitro fertilization. Method: We conducted a retrospective case-control study of 631 women aged 40-46 years, who underwent a total of 904 IVF cycles with autologous gametes. We used stepwise logistic regression analysis to develop predictors of pregnancy, clinical pregnancy and live birth outcomes. Data are presented as mean ± SD, percentage and confidence intervals. Results: Predictors of live birth included maternal (95% CI: 0.36-0.78) and paternal (95% CI: 0.62-0.94) age, the number of follicels > 14 mm (95% CI: 1.2-3.2), the number of oocytes collected (95% CI: 1.3-2.9) the number of metaphase II oocytes (95% CI: 1.3-2.4) and the number of cleavage stage embryos (95% CI: 1.8-2.6). The predictors of pregnancy and clinical pregnancy were similar but did not include male age (P > 0.05). To further determine the role of male age in live birth a control group of women younger than 40 years was collected. Male age was not a significant predictor of live birth among younger women (P = 0.42). Conclusions: Female age and better ovarian stimulation were confirmed as predictors of outcomes in older women doing IVF. However, male age was also noted to be a significant individual predictor of live birth in women over 40 years of age, but not in younger women doing IVF.
AB - Purpose: To determine which factors predict pregnancy outcome in women aged 40 years and above who underwent in-vitro fertilization. Method: We conducted a retrospective case-control study of 631 women aged 40-46 years, who underwent a total of 904 IVF cycles with autologous gametes. We used stepwise logistic regression analysis to develop predictors of pregnancy, clinical pregnancy and live birth outcomes. Data are presented as mean ± SD, percentage and confidence intervals. Results: Predictors of live birth included maternal (95% CI: 0.36-0.78) and paternal (95% CI: 0.62-0.94) age, the number of follicels > 14 mm (95% CI: 1.2-3.2), the number of oocytes collected (95% CI: 1.3-2.9) the number of metaphase II oocytes (95% CI: 1.3-2.4) and the number of cleavage stage embryos (95% CI: 1.8-2.6). The predictors of pregnancy and clinical pregnancy were similar but did not include male age (P > 0.05). To further determine the role of male age in live birth a control group of women younger than 40 years was collected. Male age was not a significant predictor of live birth among younger women (P = 0.42). Conclusions: Female age and better ovarian stimulation were confirmed as predictors of outcomes in older women doing IVF. However, male age was also noted to be a significant individual predictor of live birth in women over 40 years of age, but not in younger women doing IVF.
KW - Advanced maternal age
KW - Advanced paternal age
KW - Biologic clock
KW - IVF
KW - In-vitro fertilization
UR - http://www.scopus.com/inward/record.url?scp=85105176575&partnerID=8YFLogxK
U2 - 10.31083/j.ceog.2021.02.2275
DO - 10.31083/j.ceog.2021.02.2275
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AN - SCOPUS:85105176575
SN - 0390-6663
VL - 48
SP - 299
EP - 306
JO - Clinical and Experimental Obstetrics and Gynecology
JF - Clinical and Experimental Obstetrics and Gynecology
IS - 2
ER -