Pasa: Proteomic analysis of serum antibodies web server

Oren Avram, Aya Kigel, Anna Vaisman-Mentesh, Sharon Kligsberg, Shai Rosenstein, Yael Dror, Tal Pupko, Yariv Wine

Research output: Contribution to journalArticlepeer-review


Motivation A comprehensive characterization of the humoral response towards a specific antigen requires quantification of the B-cell receptor repertoire (BCR-Seq) by next generation sequencing, as well as the analysis of serum antibodies against this antigen, using proteomics. The proteomic analysis is challenging since it necessitates the mapping of antigen-specific peptides to individual B-cell clones. Results The PASA web server provides a robust computational platform for the analysis and integration of data obtained from proteomics of serum antibodies. PASA maps peptides derived from antibodies raised against a specific antigen to corresponding antibody sequences. It then analyzes and integrates proteomics and BCR-Seq data, thus providing a comprehensive characterization of the humoral response. The PASA web server is freely available at and open to all users without a login requirement.

Original languageEnglish
Article numbere1008607
JournalPLoS Computational Biology
Issue number1
StatePublished - 25 Jan 2021


Dive into the research topics of 'Pasa: Proteomic analysis of serum antibodies web server'. Together they form a unique fingerprint.

Cite this