Parma consensus statement on metabolic disruptors

Jerrold J. Heindel; Frederick S. Vom Saal; Bruce Blumberg; Patrizia Bovolin; Gemma Calamandrei; Graziano Ceresini; Barbara A. Cohn; Elena Fabbri; Laura Gioiosa; Christopher Kassotis; Juliette Legler; Michele La Merrill; Laura Rizzir; Ronit Machtinger; Alberto Mantovani; Michelle A. Mendez; Luisa Montanini; Laura Molteni; Susan C. Nagel; Stefano Parmigiani; Giancarlo Panzica; Silvia Paterlini; Valentina Pomatto; Jérôme Ruzzin; Giorgio Sartor; Thaddeus T. Schug; Maria E. Street; Alexander Suvorov; Riccardo Volpi; R. Thomas Zoeller; Paola Palanza

doi:10.1186/s12940-015-0042-7

Parma consensus statement on metabolic disruptors

Jerrold J. Heindel^*, Frederick S. Vom Saal, Bruce Blumberg, Patrizia Bovolin, Gemma Calamandrei, Graziano Ceresini, Barbara A. Cohn, Elena Fabbri, Laura Gioiosa, Christopher Kassotis, Juliette Legler, Michele La Merrill, Laura Rizzir, Ronit Machtinger, Alberto Mantovani, Michelle A. Mendez, Luisa Montanini, Laura Molteni, Susan C. Nagel, Stefano ParmigianiGiancarlo Panzica, Silvia Paterlini, Valentina Pomatto, Jérôme Ruzzin, Giorgio Sartor, Thaddeus T. Schug, Maria E. Street, Alexander Suvorov, Riccardo Volpi, R. Thomas Zoeller, Paola Palanza

^*Corresponding author for this work

Obstetrics & Gynecology

Research output: Contribution to journal › Review article › peer-review

168 Scopus citations

Abstract

A multidisciplinary group of experts gathered in Parma Italy for a workshop hosted by the University of Parma, May 16-18, 2014 to address concerns about the potential relationship between environmental metabolic disrupting chemicals, obesity and related metabolic disorders. The objectives of the workshop were to: 1. Review findings related to the role of environmental chemicals, referred to as "metabolic disruptors", in obesity and metabolic syndrome with special attention to recent discoveries from animal model and epidemiology studies; 2. Identify conclusions that could be drawn with confidence from existing animal and human data; 3. Develop predictions based on current data; and 4. Identify critical knowledge gaps and areas of uncertainty. The consensus statements are intended to aid in expanding understanding of the role of metabolic disruptors in the obesity and metabolic disease epidemics, to move the field forward by assessing the current state of the science and to identify research needs on the role of environmental chemical exposures in these diseases. We propose broadening the definition of obesogens to that of metabolic disruptors, to encompass chemicals that play a role in altered susceptibility to obesity, diabetes and related metabolic disorders including metabolic syndrome.

Original language	English
Article number	54
Journal	Environmental Health: A Global Access Science Source
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/s12940-015-0042-7
State	Published - 20 Jun 2015

Funding

Funders	Funder number
National Institute of Environmental Health Sciences	R01ES023316

Keywords

Developmental Programming
Diabetes
Metabolic disruptor
Metabolic syndrome
Obesity
Obesogen

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12940-015-0042-7

Cite this

Heindel, J. J., Vom Saal, F. S., Blumberg, B., Bovolin, P., Calamandrei, G., Ceresini, G., Cohn, B. A., Fabbri, E., Gioiosa, L., Kassotis, C., Legler, J., La Merrill, M., Rizzir, L., Machtinger, R., Mantovani, A., Mendez, M. A., Montanini, L., Molteni, L., Nagel, S. C., ... Palanza, P. (2015). Parma consensus statement on metabolic disruptors. Environmental Health: A Global Access Science Source, 14(1), Article 54. https://doi.org/10.1186/s12940-015-0042-7

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abstract = "A multidisciplinary group of experts gathered in Parma Italy for a workshop hosted by the University of Parma, May 16-18, 2014 to address concerns about the potential relationship between environmental metabolic disrupting chemicals, obesity and related metabolic disorders. The objectives of the workshop were to: 1. Review findings related to the role of environmental chemicals, referred to as {"}metabolic disruptors{"}, in obesity and metabolic syndrome with special attention to recent discoveries from animal model and epidemiology studies; 2. Identify conclusions that could be drawn with confidence from existing animal and human data; 3. Develop predictions based on current data; and 4. Identify critical knowledge gaps and areas of uncertainty. The consensus statements are intended to aid in expanding understanding of the role of metabolic disruptors in the obesity and metabolic disease epidemics, to move the field forward by assessing the current state of the science and to identify research needs on the role of environmental chemical exposures in these diseases. We propose broadening the definition of obesogens to that of metabolic disruptors, to encompass chemicals that play a role in altered susceptibility to obesity, diabetes and related metabolic disorders including metabolic syndrome.",

keywords = "Developmental Programming, Diabetes, Metabolic disruptor, Metabolic syndrome, Obesity, Obesogen",

author = "Heindel, {Jerrold J.} and {Vom Saal}, {Frederick S.} and Bruce Blumberg and Patrizia Bovolin and Gemma Calamandrei and Graziano Ceresini and Cohn, {Barbara A.} and Elena Fabbri and Laura Gioiosa and Christopher Kassotis and Juliette Legler and {La Merrill}, Michele and Laura Rizzir and Ronit Machtinger and Alberto Mantovani and Mendez, {Michelle A.} and Luisa Montanini and Laura Molteni and Nagel, {Susan C.} and Stefano Parmigiani and Giancarlo Panzica and Silvia Paterlini and Valentina Pomatto and J{\'e}r{\^o}me Ruzzin and Giorgio Sartor and Schug, {Thaddeus T.} and Street, {Maria E.} and Alexander Suvorov and Riccardo Volpi and Zoeller, {R. Thomas} and Paola Palanza",

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month = jun,

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doi = "10.1186/s12940-015-0042-7",

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Heindel, JJ, Vom Saal, FS, Blumberg, B, Bovolin, P, Calamandrei, G, Ceresini, G, Cohn, BA, Fabbri, E, Gioiosa, L, Kassotis, C, Legler, J, La Merrill, M, Rizzir, L, Machtinger, R, Mantovani, A, Mendez, MA, Montanini, L, Molteni, L, Nagel, SC, Parmigiani, S, Panzica, G, Paterlini, S, Pomatto, V, Ruzzin, J, Sartor, G, Schug, TT, Street, ME, Suvorov, A, Volpi, R, Zoeller, RT & Palanza, P 2015, 'Parma consensus statement on metabolic disruptors', Environmental Health: A Global Access Science Source, vol. 14, no. 1, 54. https://doi.org/10.1186/s12940-015-0042-7

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T1 - Parma consensus statement on metabolic disruptors

AU - Heindel, Jerrold J.

AU - Vom Saal, Frederick S.

AU - Blumberg, Bruce

AU - Bovolin, Patrizia

AU - Calamandrei, Gemma

AU - Ceresini, Graziano

AU - Cohn, Barbara A.

AU - Fabbri, Elena

AU - Gioiosa, Laura

AU - Kassotis, Christopher

AU - Legler, Juliette

AU - La Merrill, Michele

AU - Rizzir, Laura

AU - Machtinger, Ronit

AU - Mantovani, Alberto

AU - Mendez, Michelle A.

AU - Montanini, Luisa

AU - Molteni, Laura

AU - Nagel, Susan C.

AU - Parmigiani, Stefano

AU - Panzica, Giancarlo

AU - Paterlini, Silvia

AU - Pomatto, Valentina

AU - Ruzzin, Jérôme

AU - Sartor, Giorgio

AU - Schug, Thaddeus T.

AU - Street, Maria E.

AU - Suvorov, Alexander

AU - Volpi, Riccardo

AU - Zoeller, R. Thomas

AU - Palanza, Paola

PY - 2015/6/20

Y1 - 2015/6/20

N2 - A multidisciplinary group of experts gathered in Parma Italy for a workshop hosted by the University of Parma, May 16-18, 2014 to address concerns about the potential relationship between environmental metabolic disrupting chemicals, obesity and related metabolic disorders. The objectives of the workshop were to: 1. Review findings related to the role of environmental chemicals, referred to as "metabolic disruptors", in obesity and metabolic syndrome with special attention to recent discoveries from animal model and epidemiology studies; 2. Identify conclusions that could be drawn with confidence from existing animal and human data; 3. Develop predictions based on current data; and 4. Identify critical knowledge gaps and areas of uncertainty. The consensus statements are intended to aid in expanding understanding of the role of metabolic disruptors in the obesity and metabolic disease epidemics, to move the field forward by assessing the current state of the science and to identify research needs on the role of environmental chemical exposures in these diseases. We propose broadening the definition of obesogens to that of metabolic disruptors, to encompass chemicals that play a role in altered susceptibility to obesity, diabetes and related metabolic disorders including metabolic syndrome.

AB - A multidisciplinary group of experts gathered in Parma Italy for a workshop hosted by the University of Parma, May 16-18, 2014 to address concerns about the potential relationship between environmental metabolic disrupting chemicals, obesity and related metabolic disorders. The objectives of the workshop were to: 1. Review findings related to the role of environmental chemicals, referred to as "metabolic disruptors", in obesity and metabolic syndrome with special attention to recent discoveries from animal model and epidemiology studies; 2. Identify conclusions that could be drawn with confidence from existing animal and human data; 3. Develop predictions based on current data; and 4. Identify critical knowledge gaps and areas of uncertainty. The consensus statements are intended to aid in expanding understanding of the role of metabolic disruptors in the obesity and metabolic disease epidemics, to move the field forward by assessing the current state of the science and to identify research needs on the role of environmental chemical exposures in these diseases. We propose broadening the definition of obesogens to that of metabolic disruptors, to encompass chemicals that play a role in altered susceptibility to obesity, diabetes and related metabolic disorders including metabolic syndrome.

KW - Developmental Programming

KW - Diabetes

KW - Metabolic disruptor

KW - Metabolic syndrome

KW - Obesity

KW - Obesogen

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ER -

Parma consensus statement on metabolic disruptors

Abstract

Funding

Keywords

UN SDGs

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