Parkinson's disease: Before the motor symptoms and beyond

Amos D. Korczyn, Tanya Gurevich

Research output: Contribution to journalArticlepeer-review


The understanding of the biology of Parkinson's disease (PD) has advanced rapidly over the past 3 decades. In particular, the early pathological changes described by Braak et al. and the awareness of extensive and clinically relevant premotor manifestations are of diagnostic and therapeutic importance. We review those manifestations and their contribution to the clarification of the pathophysiologic processes of PD, and discuss the implications for treatment of the disease.

Original languageEnglish
Pages (from-to)2-6
Number of pages5
JournalJournal of the Neurological Sciences
Issue number1-2
StatePublished - 15 Feb 2010


  • Autocorrelation
  • Connectivity
  • Individual-based models
  • Landscape genetics
  • Object-oriented programming


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