TY - JOUR
T1 - Parkinson's disease
T2 - Before the motor symptoms and beyond
AU - Korczyn, Amos D.
AU - Gurevich, Tanya
PY - 2010/2/15
Y1 - 2010/2/15
N2 - The understanding of the biology of Parkinson's disease (PD) has advanced rapidly over the past 3 decades. In particular, the early pathological changes described by Braak et al. and the awareness of extensive and clinically relevant premotor manifestations are of diagnostic and therapeutic importance. We review those manifestations and their contribution to the clarification of the pathophysiologic processes of PD, and discuss the implications for treatment of the disease.
AB - The understanding of the biology of Parkinson's disease (PD) has advanced rapidly over the past 3 decades. In particular, the early pathological changes described by Braak et al. and the awareness of extensive and clinically relevant premotor manifestations are of diagnostic and therapeutic importance. We review those manifestations and their contribution to the clarification of the pathophysiologic processes of PD, and discuss the implications for treatment of the disease.
KW - Autocorrelation
KW - Connectivity
KW - Individual-based models
KW - Landscape genetics
KW - Object-oriented programming
UR - http://www.scopus.com/inward/record.url?scp=74149088543&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2009.08.032
DO - 10.1016/j.jns.2009.08.032
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C2 - 19801155
AN - SCOPUS:74149088543
VL - 289
SP - 2
EP - 6
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
IS - 1-2
ER -