TY - JOUR
T1 - Paraventricular nucleus serotonin mediates neurally stimulated adrenocortical secretion
AU - Feldman, Shaul
AU - Conforti, Nissim
AU - Melamed, Eldad
PY - 1987/2
Y1 - 1987/2
N2 - The purpose of this study was to further elucidate the role of serotonin (5-HT) in adrenocortieal regulation. The effects of stimulating the frontal cortex and extrahypothalamic limbic structures, on plasma corticosterone (CS) responses, were studied in rats with vehicle or 5,7-dihydroxytryptamine (5,7-DHT) injection into the midbrain raphe nuclei. In another group of rats the neurotoxin was injected locally into the paraventricular nucleus (PVN) in view of its importance in adrenocortical regulation, and the effects of photic and dorsal hippocampal stimulation on plasma CS were studied. 5,7-DHT caused a significant depletion of hypothalamic 5-HT and blocked the rise in plasma CS following the stimulation of the above neural modalities. These studies suggest that the PVN 5-HT mediates the adrenocortical responses following afferent neural stimuli.
AB - The purpose of this study was to further elucidate the role of serotonin (5-HT) in adrenocortieal regulation. The effects of stimulating the frontal cortex and extrahypothalamic limbic structures, on plasma corticosterone (CS) responses, were studied in rats with vehicle or 5,7-dihydroxytryptamine (5,7-DHT) injection into the midbrain raphe nuclei. In another group of rats the neurotoxin was injected locally into the paraventricular nucleus (PVN) in view of its importance in adrenocortical regulation, and the effects of photic and dorsal hippocampal stimulation on plasma CS were studied. 5,7-DHT caused a significant depletion of hypothalamic 5-HT and blocked the rise in plasma CS following the stimulation of the above neural modalities. These studies suggest that the PVN 5-HT mediates the adrenocortical responses following afferent neural stimuli.
KW - Corticosterone secretion
KW - Neural stimuli
KW - Paraventricular nucleus
KW - Serotonin 5,7,-Dihydroxytryptamine
UR - http://www.scopus.com/inward/record.url?scp=0023110820&partnerID=8YFLogxK
U2 - 10.1016/0361-9230(87)90186-9
DO - 10.1016/0361-9230(87)90186-9
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AN - SCOPUS:0023110820
SN - 0361-9230
VL - 18
SP - 165
EP - 168
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 2
ER -