Paravalvular regurgitation after transcatheter aortic valve replacement: Diagnosis, clinical outcome, preventive and therapeutic strategies

Danny Dvir; Israel M. Barbash; Itsik Ben-Dor; Rebecca Torguson; Salem Badr; Sa'ar Minha; Lakshmana K. Pendyala; Joshua P. Loh; Augusto D. Pichard; Ron Waksman

doi:10.1016/j.carrev.2013.02.003

Paravalvular regurgitation after transcatheter aortic valve replacement: Diagnosis, clinical outcome, preventive and therapeutic strategies

Danny Dvir, Israel M. Barbash, Itsik Ben-Dor, Rebecca Torguson, Salem Badr, Sa'ar Minha, Lakshmana K. Pendyala, Joshua P. Loh, Augusto D. Pichard, Ron Waksman^*

^*Corresponding author for this work

Washington Hospital Center

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Paravalvular regurgitation is a common, potentially life-threatening complication of transcatheter aortic valve replacement. Previous studies report a 65%-94% rate of paravalvular leakage after transcatheter implantation, mostly of mild degree. The rate of significant (≥. +. 2) paravalvular regurgitation varies in large clinical trials, and is associated with worse clinical outcome. There is less agreement regarding the significance of mild regurgitation (grade 1. +). There are anatomical and procedural correlates for paravalvular leak-most importantly, severe valve calcification, patient prosthetic mismatch, and device malposition. The following review details the current knowledge on paravalvular regurgitation after transcatheter aortic valve replacement, including diagnosis, correlates, clinical outcome, preventive and therapeutic strategies related to this complication.

Original language	English
Pages (from-to)	174-181
Number of pages	8
Journal	Cardiovascular Revascularization Medicine
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/j.carrev.2013.02.003
State	Published - May 2013
Externally published	Yes

Keywords

Aortic valve stenosis
Paravalvular regurgitation
Transcatheter aortic valve implantation

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10.1016/j.carrev.2013.02.003

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Dvir, D., Barbash, I. M., Ben-Dor, I., Torguson, R., Badr, S., Minha, S., Pendyala, L. K., Loh, J. P., Pichard, A. D., & Waksman, R. (2013). Paravalvular regurgitation after transcatheter aortic valve replacement: Diagnosis, clinical outcome, preventive and therapeutic strategies. Cardiovascular Revascularization Medicine, 14(3), 174-181. https://doi.org/10.1016/j.carrev.2013.02.003

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title = "Paravalvular regurgitation after transcatheter aortic valve replacement: Diagnosis, clinical outcome, preventive and therapeutic strategies",

abstract = "Paravalvular regurgitation is a common, potentially life-threatening complication of transcatheter aortic valve replacement. Previous studies report a 65%-94% rate of paravalvular leakage after transcatheter implantation, mostly of mild degree. The rate of significant (≥. +. 2) paravalvular regurgitation varies in large clinical trials, and is associated with worse clinical outcome. There is less agreement regarding the significance of mild regurgitation (grade 1. +). There are anatomical and procedural correlates for paravalvular leak-most importantly, severe valve calcification, patient prosthetic mismatch, and device malposition. The following review details the current knowledge on paravalvular regurgitation after transcatheter aortic valve replacement, including diagnosis, correlates, clinical outcome, preventive and therapeutic strategies related to this complication.",

keywords = "Aortic valve stenosis, Paravalvular regurgitation, Transcatheter aortic valve implantation",

author = "Danny Dvir and Barbash, {Israel M.} and Itsik Ben-Dor and Rebecca Torguson and Salem Badr and Sa'ar Minha and Pendyala, {Lakshmana K.} and Loh, {Joshua P.} and Pichard, {Augusto D.} and Ron Waksman",

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doi = "10.1016/j.carrev.2013.02.003",

language = "אנגלית",

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Dvir, D, Barbash, IM, Ben-Dor, I, Torguson, R, Badr, S, Minha, S, Pendyala, LK, Loh, JP, Pichard, AD & Waksman, R 2013, 'Paravalvular regurgitation after transcatheter aortic valve replacement: Diagnosis, clinical outcome, preventive and therapeutic strategies', Cardiovascular Revascularization Medicine, vol. 14, no. 3, pp. 174-181. https://doi.org/10.1016/j.carrev.2013.02.003

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AU - Barbash, Israel M.

AU - Ben-Dor, Itsik

AU - Torguson, Rebecca

AU - Badr, Salem

AU - Minha, Sa'ar

AU - Pendyala, Lakshmana K.

AU - Loh, Joshua P.

AU - Pichard, Augusto D.

AU - Waksman, Ron

PY - 2013/5

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KW - Paravalvular regurgitation

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Paravalvular regurgitation after transcatheter aortic valve replacement: Diagnosis, clinical outcome, preventive and therapeutic strategies

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