Paraoxonase (PON)1 192R allele carriage is associated with reduced risk of inflammatory bowel disease

Amir Karban, Corina Hartman, Rami Eliakim, Matti Waterman, Shula Nesher, Ofra Barnett-Griness, Raanan Shamir

Research output: Contribution to journalArticlepeer-review

Abstract

The paraoxonase (PON) genes family maps to chromosome 7q21-q22, within a loci that also showed evidence of susceptibility genes for both Crohn's disease (CD) and ulcerative colitis (UC). In this case-control study we investigated the possible relationship between PON1 and PON2 polymorphisms and the risk of inflammatory bowel disease (IBD). PON1 192Q/R, PON1 55L/M, and PON2 311S/C polymorphisms were investigated by RFLP analysis in DNA samples from 224 patients with CD, 58 patients with UC, and 311 healthy controls. The PON1 192R allele was significantly less common among IBD Ashkenazi patients (allelic OR = 0.61, P = 0.004, 95% CI = 0.44-0.85). In agreement with the individual SNP analysis, Ashkenazi IBD patients had a higher frequency of haplotype PON1 192Q/PON1 55L/PON2 311S (26.3% vs 17.3%; P=0.003) and a lower frequency of haplotype PON1 192R/PON1 55L/PON2 311S (18.9% vs 27.7%; P=0.008). Our results suggest that in this Ashkenazi Jewish population, carriage of PON1 R192 allele may confer protection against the development of IBD.

Original languageEnglish
Pages (from-to)2707-2715
Number of pages9
JournalDigestive Diseases and Sciences
Volume52
Issue number10
DOIs
StatePublished - Oct 2007
Externally publishedYes

Keywords

  • Crohn's disease
  • Inflammatory bowel disease
  • Lactonase
  • Paraoxonase
  • Polymorphism

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