TY - JOUR
T1 - Parameters that influence the results of in vitro fertilization/embryo transfer
T2 - A study of an egg donation model
AU - Levran, D.
AU - Goldstein, I.
AU - Dor, J.
AU - Mashiach, S.
AU - Bider, D.
PY - 1996
Y1 - 1996
N2 - A retrospective analysis was carried our after ovulation induction in donors, and treatment outcome in donors and recipients, relating to variables such as: age, protocol of ovarian stimulation, transfer of fresh or cryopreserved embryos, number of embryos transferred including quality and etiology of donor and recipient infertility. The recipients underwent 214 cycles of embryo transfer from 82 different donors. Forty-five (21%) pregnancies were recorded. The age of the recipients significantly affected the conception rate (pregnancy rate of 30% on those aged < 30 years, compared to 9.7% in those aged > 44 years) and the donors were contributed more to pregnancies were younger. The pregnancy rate was significantly higher when fresh embryos were transferred to recipients (28%, compared to 15% when cryopreserved embryos were transferred). In addition, the number of embryos transferred affected the pregnancy rate ≤ 3 embryos were transferred and, if they were of good quality, the success was significantly higher. Ultimately, when the ovarian stimulation protocol was clomiphene citrate and human menopausal gonadotropin or gonadotropin-releasing hormone agonist/follicle-stimulating hormone/human menopausal gonadotropin, and the etiology of infertility was polycystic ovarian disease in the donors, the success rate was significantly increased in the recipients.
AB - A retrospective analysis was carried our after ovulation induction in donors, and treatment outcome in donors and recipients, relating to variables such as: age, protocol of ovarian stimulation, transfer of fresh or cryopreserved embryos, number of embryos transferred including quality and etiology of donor and recipient infertility. The recipients underwent 214 cycles of embryo transfer from 82 different donors. Forty-five (21%) pregnancies were recorded. The age of the recipients significantly affected the conception rate (pregnancy rate of 30% on those aged < 30 years, compared to 9.7% in those aged > 44 years) and the donors were contributed more to pregnancies were younger. The pregnancy rate was significantly higher when fresh embryos were transferred to recipients (28%, compared to 15% when cryopreserved embryos were transferred). In addition, the number of embryos transferred affected the pregnancy rate ≤ 3 embryos were transferred and, if they were of good quality, the success was significantly higher. Ultimately, when the ovarian stimulation protocol was clomiphene citrate and human menopausal gonadotropin or gonadotropin-releasing hormone agonist/follicle-stimulating hormone/human menopausal gonadotropin, and the etiology of infertility was polycystic ovarian disease in the donors, the success rate was significantly increased in the recipients.
KW - Egg donation
KW - Embryo transfer parameters
KW - In vitro fertilization
UR - http://www.scopus.com/inward/record.url?scp=0030467671&partnerID=8YFLogxK
U2 - 10.3109/09513599609023604
DO - 10.3109/09513599609023604
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C2 - 9032567
AN - SCOPUS:0030467671
SN - 0951-3590
VL - 10
SP - 401
EP - 406
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
IS - 6
ER -