Parachlorophenylalanine Reversal of Tranylcypromine Effects in Depressed Patients

Baron Shopsin, Eitan Friedman, Samuel Gershon

Research output: Contribution to journalArticlepeer-review


Hospitalized bipolar and unipolar endogenously depressed patients who showed an antidepressant response to the monoamine oxidase (MAO) inhibitor, tranylcypromine sulfate, relapsed (ie, depression returned) when relatively small doses of parachlorophenylalanine (PCPA) were added for brief periods. Considered together with our findings that PCPA similarly reversed the antidepressant effects of the tricyclic drug, imipramine hydrochloride, implications are (1) serotonergic mechanisms are likely involved in the antidepressant effects of both the tricyclic drugs and MAO inhibitors in man and (2) this indolamine may also play a role in the endogenous clinical state of depression.

Original languageEnglish
Pages (from-to)811-819
Number of pages9
JournalArchives of General Psychiatry
Issue number7
StatePublished - Jul 1976
Externally publishedYes


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