Pancytopenia resulting from hemophagocytosis in malaria

Alex Zvulunov*, Hannah Tamary, Nathan Gal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Pancytopenia in an acutely ill child is commonly a result of bone marrow suppression. Rarely pancytopenia is a manifestation of inappropriate macrophage activation associated with hemophagocytosis. Viral infections account for most cases of secondary hemophagocytosis. We report a case of malaria-associated hemophagocytosis in a child from an endemic area. Systemic parasitic infections should be included in the differential diagnosis of pancytopenia and infection-associated hemophagocytosis. In this rare subgroup of hemophagocytosis, malaria caused by Plasmodium falciparum is the most common parasitic infection.

Original languageEnglish
Pages (from-to)1086-1088
Number of pages3
JournalPediatric Infectious Disease Journal
Issue number11
StatePublished - 1 Nov 2002


  • Hemophagocytosis
  • Malaria
  • Pancytopenia


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