Pancreatic Pericytes in Glucose Homeostasis and Diabetes

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Glucose homeostasis relies on tightly regulated insulin secretion from pancreatic beta-cells, and its loss in diabetes is associated with the dysfunction of these cells. Beta-cells reside in the islets of Langerhans, which are highly vascularized by a dense capillary network comprised of endothelial cells and pericytes. While the requirement of the endothelium for the proper pancreatic function is well established, the role of pancreatic pericytes has only recently begun to unveil. Recent studies described multiple roles for pancreatic pericytes in glucose homeostasis, highlighting their function as both regulators of islet blood flow and as a source of critical signals that support proper beta-cell function and mass. Furthermore, recent findings point to the contribution of pericytic abnormalities to beta-cell dysfunction in type 2 diabetes, implicating the involvement of pancreatic pericytes in both the initiation and the progression of this disease. This newly gained data implicate pancreatic pericytes as critical components of the cellular network required for glucose regulation.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages27-40
Number of pages14
DOIs
StatePublished - 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1122
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Beta-cell dysfunction
  • Beta-cell function
  • Beta-cell mass
  • Beta-cells
  • Glucose homeostasis
  • Glucose-stimulated insulin secretion
  • Islet capillaries
  • Islet pericytes
  • Islet vasculature
  • Islets of Langerhans
  • Pancreatic pericytes
  • Type 2 diabetes

Fingerprint

Dive into the research topics of 'Pancreatic Pericytes in Glucose Homeostasis and Diabetes'. Together they form a unique fingerprint.

Cite this