Pancreas organogenesis: Approaches to elucidate the role of epithelial-mesenchymal interactions

Lina Sakhneny, Laura Khalifa-Malka, Limor Landsman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Pancreas organogenesis depends on proper interactions of endoderm-derived epithelial cells, which will form the exocrine and endocrine cells of the adult organ, with their surrounding mesenchymal layer. Research on the role of pancreatic mesenchyme, pioneered by Golosow and Grobstein in the 1960’s, revealed these cells regulate multiple events during pancreas development. Still, much is unknown regards the molecular basis of epithelial-mesenchymal interactions in this process. Here, we review in vivo and ex vivo approaches to study mesenchymal requirements for mammal pancreas organogenesis, and how gained knowledge is being translated toward the development of cell replacement therapy for diabetes.

Original languageEnglish
Pages (from-to)89-96
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume92
DOIs
StatePublished - Aug 2019

Funding

FundersFunder number
Center for Absorption in Science
Israel Ministry of Aliyah and Integration
German-Israeli Foundation for Scientific Research and DevelopmentI-1308-203.13/2015
European Association for the Study of Diabetes

    Keywords

    • Beta-cells
    • Embryonic development
    • Pancreas
    • Pancreas development
    • Pancreatic mesenchyme
    • Pancreatic mesoderm
    • Pancreatic progenitors
    • Stem-cell derived beta-cells

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