Pamidronate-induced nephrotoxic tubular necrosis - A case report

S. Smetana*, A. Michlin, E. Rosenman, A. Biro, M. Boaz, Z. Katzir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Few cases of pamidronate (bis-phosphonate class of drugs) nephrotoxicity in humans have been previously reported in the literature. In 7 patients, the pamidronate-related nephrotoxicity was attributed to focal collapsing glomerulosclerosis [Markowitz et al. 2001], and in 1 patient was related to tubulo-interstitial inflammatory nephritis [Van Doorn et al. 2001]. We report herein on a 65-year-old Caucasian female patient who presented with acute chronic renal failure due to pamidronate-induced toxic proximal tubular necrosis without immunologic or inflammatory tubulo-interstitial involvement. The acute pattern of renal failure resolved following cessation of pamidronate administration in this patient for osteoporosis; the patient also had a monoclonal gammopathy of unspecific origin (MGUS).

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalClinical Nephrology
Issue number1
StatePublished - Jan 2004
Externally publishedYes


  • MGUS
  • Nephrotoxicity
  • Pamidronate
  • Tubular necrosis


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