TY - JOUR
T1 - Palpitation in women with silicone breast implants
T2 - association with autoantibodies against autonomic nervous system
AU - Elroy, Tal
AU - Halpert, Gilad
AU - Tsur, Avishai M.
AU - Heidecke, Harald
AU - Amital, Howard
AU - Shoenfeld, Yehuda
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2024/2
Y1 - 2024/2
N2 - We explored a possible association between palpitation manifestation in women with silicone breast implants (SBIs) with circulating level of autoantibodies directed against autonomic nervous system (ANS) receptors. The study was conducted in 93 women with SBIs who arrived to our clinic with diverse symptoms thought to be associated with their implants. Titers of 11 various autoantibodies were measured in the sera of women with SBIs who experienced palpitations (Palpitations, n = 47), did not experience palpitations (Non, n = 46), and healthy women (Control, n = 36). A significant reduction in anti-α2-adrenergic receptor (A2AR, P = 0.035), anti-β2-adrenergic receptor (B2AR, P = 0.027), antimuscarinic receptors M1R (P = 0.048), and anti-M2R (P = 0.039) autoantibodies was found in the ‘Palpitations’ group as compared with the ‘Non’ group. Anti-B2AR (P = 0.042), anti-M1R (P = 0.017), and anti-M2R (P = 0.0015) autoantibodies were also significantly reduced in ‘Palpitations’ as compared with the ‘Control’ group. Our study shows possible association between autoantibodies directed against ANS receptors, with existing complaints of palpitations in women with SBIs.
AB - We explored a possible association between palpitation manifestation in women with silicone breast implants (SBIs) with circulating level of autoantibodies directed against autonomic nervous system (ANS) receptors. The study was conducted in 93 women with SBIs who arrived to our clinic with diverse symptoms thought to be associated with their implants. Titers of 11 various autoantibodies were measured in the sera of women with SBIs who experienced palpitations (Palpitations, n = 47), did not experience palpitations (Non, n = 46), and healthy women (Control, n = 36). A significant reduction in anti-α2-adrenergic receptor (A2AR, P = 0.035), anti-β2-adrenergic receptor (B2AR, P = 0.027), antimuscarinic receptors M1R (P = 0.048), and anti-M2R (P = 0.039) autoantibodies was found in the ‘Palpitations’ group as compared with the ‘Non’ group. Anti-B2AR (P = 0.042), anti-M1R (P = 0.017), and anti-M2R (P = 0.0015) autoantibodies were also significantly reduced in ‘Palpitations’ as compared with the ‘Control’ group. Our study shows possible association between autoantibodies directed against ANS receptors, with existing complaints of palpitations in women with SBIs.
KW - Adrenergic receptors
KW - Autoantibodies
KW - Autoimmune Syndrome Induced by Adjuvants (ASIA)
KW - Autoimmune disease
KW - Autoimmunity
KW - Autonomic nervous system
KW - G protein-coupled receptors (GPCR)
KW - Muscarinic receptors
KW - Palpitations
KW - Silicone breast implants
UR - http://www.scopus.com/inward/record.url?scp=85174264878&partnerID=8YFLogxK
U2 - 10.1007/s12026-023-09425-w
DO - 10.1007/s12026-023-09425-w
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C2 - 37845561
AN - SCOPUS:85174264878
SN - 0257-277X
VL - 72
SP - 155
EP - 161
JO - Immunologic Research
JF - Immunologic Research
IS - 1
ER -