Palmoplantar psoriasis: Experience with 8-methoxypsoralen soaks plus ultraviolet A with the use of a high-output metal halide device

William R. Coleman, Nicholas J. Lowe*, Michael David

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The use of 8-methoxypsoralen water soaks plus ultraviolet A was evaluated retrospectively in 11 patients with moderate to severe palmoplantar psoriasis that had been resistant to previous topical therapies. Patients received twice- or thrice-weekly 30-minute hand and/or foot soaks in 8-methoxypsoralen, 2.5 mg/L, followed by UVA irradiation. The condition of one patient cleared completely, and seven showed good improvement. The range of treatments required for maximal improvement was 14 to 43 with a mean of 28. The range of maximum UVA dosage per treatment was 3.5 to 17.5 joules/cm2, and the range of cumulative UVA required for maximal improvement was 45 to 388 joules/cm2 with a mean of 165 joules/cm2. The mean serum level of 8-methoxypsoralen 60 minutes after completion of hand and foot soaks was 2.5 ± 0.5 ng/ml compared with 95.75 ± 10.43 ng/ml after oral 8-methoxypsoralen, 0.5 mg/kg. In our experience this treatment has been a safe and relatively effective form of therapy for resistant palmoplantar psoriasis.

Original languageEnglish
Pages (from-to)1078-1082
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume20
Issue number6
DOIs
StatePublished - 1989

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