Abstract
An efficient native chemical ligation approach at Asp and Glu sites is reported applying a hydrazide precursor, as a peptide thioester, and allyl protection at the side chain of Asp and Glu. The allyl protection was efficiently removed, after the ligation step, using the water-soluble palladium complex [Pd(allyl)Cl]2 and glutathione within a few minutes under fully aqueous conditions.
Original language | English |
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Pages (from-to) | 4061-4064 |
Number of pages | 4 |
Journal | Organic and Biomolecular Chemistry |
Volume | 16 |
Issue number | 22 |
DOIs | |
State | Published - 2018 |
Externally published | Yes |