Paediatric otogenic sinus venous thrombosis: the role of Fusobacterium necrophorum

Translated title of the contribution: Paediatric otogenic sinus venous thrombosis: the role of Fusobacterium necrophorum

Eyal Yosefof*, Ohad Hilly, Meirav Sokolov, Eyal Raveh, Joanne Yacobovich, David Ulanovski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives. Sinus venous thrombosis (SVT) is a rare complication of acute otitis media (AOM) with acute mastoiditis (AM), which during recent years has been associated with Fusobacterium necrophorum (Fn) infection. Our objective was to review clinical, micro-biologic, and hematologic features of paediatric otogenic SVT, with a specific focus on the role of Fn. Methods. A retrospective database review in a tertiary paediatric hospital between 2000-2019. Results. Fifty children aged 6-155 months were treated for AM with SVT. Forty-seven (94%) underwent cortical mastoidectomy. Forty-six children received low-molecular-weight heparin (LMWH). Follow-up imaging revealed recanalisation in 92% of cases. No long-term neurologic or haematologic complications were observed. Since 2014, when anaerobic cultures and PCR were routinely used in our institute, Fn was isolated from 15/21 children with SVT. Their time to recanalisation was longer, and the rate of lupus anticoagulant antibodies (LAC) was higher than in the 6 non-Fn patients. Children positive for LAC also had a longer time to recanalisation. Conclusions. Fn is a common pathogen in AM with SVT; its thrombogenic role was demonstrated by a higher prevalence of LAC and a longer time to recanalisation.

Translated title of the contributionPaediatric otogenic sinus venous thrombosis: the role of Fusobacterium necrophorum
Original languageEnglish
Pages (from-to)388-394
Number of pages7
JournalActa Otorhinolaryngologica Italica
Volume42
Issue number4
DOIs
StatePublished - Aug 2022

Keywords

  • Fusobacterium necrophorum
  • mastoiditis
  • sinus thrombosis

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