p53 staining correlates with tumor type and location in sebaceous neoplasms

Sara C. Shalin, Aniket Sakharpe, Stephen Lyle, Dina Lev, Eduardo Calonje, Alexander J. Lazar

Research output: Contribution to journalArticlepeer-review

Abstract

Sebaceous neoplasms are commonly considered in their relationship to the Muir-Torre syndrome and the now well-documented loss of DNA mismatch repair proteins leading to microsatellite instability. However, sebaceous neoplasms showing microsatellite instability comprise only a subset of this group of tumors, and thus, alternative tumorigenic mechanisms must exist. This article explores the relationship of p53, a tumor suppressor implicated in other cutaneous malignancies, and sebaceous neoplasia. We examined 94 sebaceous tumors from 92 patients. Tumors with strong nuclear p53 staining were significantly associated with the diagnosis of sebaceous carcinoma compared with benign sebaceous lesions, most notably for periocular carcinomas. Importantly, nuclear mismatch repair protein expression was intact in all lesions showing p53 alterations, suggesting that p53 dysfunction may represent a divergent pathway in the molecular pathogenesis of these tumors.

Original languageEnglish
Pages (from-to)129-138
Number of pages10
JournalAmerican Journal of Dermatopathology
Volume34
Issue number2
DOIs
StatePublished - Apr 2012
Externally publishedYes

Keywords

  • DNA mismatch repair
  • microsatellite instability
  • Muir-Torre syndrome
  • p53
  • sebaceoma
  • sebaceous adenoma
  • sebaceous carcinoma

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