Oxygen monitoring during photodynamic therapy

B. J. Tromberg; S. Kirnd; A. Orenstein; J. S. Nelson; M. W. Berns

doi:10.1117/12.2283667

Oxygen monitoring during photodynamic therapy

B. J. Tromberg, S. Kirnd, A. Orenstein, J. S. Nelson, M. W. Berns

Research output: Contribution to journal › Conference article › peer-review

Abstract

Electrochemical measurements of transcutaneous tumor oxygen tension are combined with compartmentalized modeling techniques in order to develop a more complete picture of the early, oxygen-dependent events during photodynamic therapy (PDT). Irradiation of Photofrin II-treated VX-2 skin carcinomas in rabbit ears results in severe local oxygen depletion which is proportional to the applied light dose. For 50 mW/cm2 irradiations (at 630 nm), energy fluences of approximately 200- 300 kJ/m2 are required to irreversibly deplete tumor transcutaneous oxygen levels. Light-induced structural damage further decreases tumor oxygen tension by disrupting blood flow. Measured and modeled tumor oxygen depletion rates are used to estimate the production of cytotoxic oxygen intermediates as well as provide a qualitative assessment of tumor circulatory status.

Original language	English
Article number	1030605
Pages (from-to)	64-70
Number of pages	7
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	10306
DOIs	https://doi.org/10.1117/12.2283667
State	Published - 21 Jul 1990
Externally published	Yes
Event	Future Directions and Applications in Photodynamic Therapy 1990 - San Diego, United States Duration: 19 Jan 1990 → 21 Jan 1990

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title = "Oxygen monitoring during photodynamic therapy",

abstract = "Electrochemical measurements of transcutaneous tumor oxygen tension are combined with compartmentalized modeling techniques in order to develop a more complete picture of the early, oxygen-dependent events during photodynamic therapy (PDT). Irradiation of Photofrin II-treated VX-2 skin carcinomas in rabbit ears results in severe local oxygen depletion which is proportional to the applied light dose. For 50 mW/cm2 irradiations (at 630 nm), energy fluences of approximately 200- 300 kJ/m2 are required to irreversibly deplete tumor transcutaneous oxygen levels. Light-induced structural damage further decreases tumor oxygen tension by disrupting blood flow. Measured and modeled tumor oxygen depletion rates are used to estimate the production of cytotoxic oxygen intermediates as well as provide a qualitative assessment of tumor circulatory status.",

author = "Tromberg, {B. J.} and S. Kirnd and A. Orenstein and Nelson, {J. S.} and Berns, {M. W.}",

note = "Publisher Copyright: {\textcopyright} 1990 SPIE.; Future Directions and Applications in Photodynamic Therapy 1990 ; Conference date: 19-01-1990 Through 21-01-1990",

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TY - JOUR

T1 - Oxygen monitoring during photodynamic therapy

AU - Tromberg, B. J.

AU - Kirnd, S.

AU - Orenstein, A.

AU - Nelson, J. S.

AU - Berns, M. W.

PY - 1990/7/21

Y1 - 1990/7/21

N2 - Electrochemical measurements of transcutaneous tumor oxygen tension are combined with compartmentalized modeling techniques in order to develop a more complete picture of the early, oxygen-dependent events during photodynamic therapy (PDT). Irradiation of Photofrin II-treated VX-2 skin carcinomas in rabbit ears results in severe local oxygen depletion which is proportional to the applied light dose. For 50 mW/cm2 irradiations (at 630 nm), energy fluences of approximately 200- 300 kJ/m2 are required to irreversibly deplete tumor transcutaneous oxygen levels. Light-induced structural damage further decreases tumor oxygen tension by disrupting blood flow. Measured and modeled tumor oxygen depletion rates are used to estimate the production of cytotoxic oxygen intermediates as well as provide a qualitative assessment of tumor circulatory status.

AB - Electrochemical measurements of transcutaneous tumor oxygen tension are combined with compartmentalized modeling techniques in order to develop a more complete picture of the early, oxygen-dependent events during photodynamic therapy (PDT). Irradiation of Photofrin II-treated VX-2 skin carcinomas in rabbit ears results in severe local oxygen depletion which is proportional to the applied light dose. For 50 mW/cm2 irradiations (at 630 nm), energy fluences of approximately 200- 300 kJ/m2 are required to irreversibly deplete tumor transcutaneous oxygen levels. Light-induced structural damage further decreases tumor oxygen tension by disrupting blood flow. Measured and modeled tumor oxygen depletion rates are used to estimate the production of cytotoxic oxygen intermediates as well as provide a qualitative assessment of tumor circulatory status.

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JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

M1 - 1030605

T2 - Future Directions and Applications in Photodynamic Therapy 1990

Y2 - 19 January 1990 through 21 January 1990

ER -

Oxygen monitoring during photodynamic therapy

Abstract

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