TY - JOUR
T1 - Oxidative stress in the fetal circulation does not depend on mode of delivery
AU - Fogel, Itay
AU - Pinchuk, Ilya
AU - Kupferminc, Michael J.
AU - Lichtenberg, Dov
AU - Fainaru, Ofer
PY - 2005/7
Y1 - 2005/7
N2 - Objective: We tested whether neonates are subject to oxidative stress by comparing the susceptibility of umbilical blood lipids with copper-induced peroxidation. Study design: Umbilical arterial and venous blood samples were drawn from 32 pregnant women who delivered by elective cesarean section (CS) and from 32 pregnant women who delivered by spontaneous vaginal delivery (SVD) in a tertiary care center. Oxidative stress was evaluated by spectrophotometric monitoring of copper-induced peroxidation of serum samples. Results: The lag preceding lipid peroxidation in umbilical arterial blood was shorter than the lag in umbilical venous blood, irrespective of mode of delivery (14.0 ± 1.8 vs 50.6 ± 8.25 min, P = .0004 in SVD group; 17.7 ± 1.6 vs 39.2 ± 7.6 min, P = .006 in CS group). Conclusion: Umbilical arterial lipids are more susceptible to peroxidation than umbilical venous lipids, indicating high oxidative stress in the fetal circulation irrespective of mode of delivery.
AB - Objective: We tested whether neonates are subject to oxidative stress by comparing the susceptibility of umbilical blood lipids with copper-induced peroxidation. Study design: Umbilical arterial and venous blood samples were drawn from 32 pregnant women who delivered by elective cesarean section (CS) and from 32 pregnant women who delivered by spontaneous vaginal delivery (SVD) in a tertiary care center. Oxidative stress was evaluated by spectrophotometric monitoring of copper-induced peroxidation of serum samples. Results: The lag preceding lipid peroxidation in umbilical arterial blood was shorter than the lag in umbilical venous blood, irrespective of mode of delivery (14.0 ± 1.8 vs 50.6 ± 8.25 min, P = .0004 in SVD group; 17.7 ± 1.6 vs 39.2 ± 7.6 min, P = .006 in CS group). Conclusion: Umbilical arterial lipids are more susceptible to peroxidation than umbilical venous lipids, indicating high oxidative stress in the fetal circulation irrespective of mode of delivery.
KW - Lipid peroxidation
KW - Oxidative stress
KW - Umbilical blood
UR - http://www.scopus.com/inward/record.url?scp=22244467089&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2004.10.637
DO - 10.1016/j.ajog.2004.10.637
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AN - SCOPUS:22244467089
SN - 0002-9378
VL - 193
SP - 241
EP - 246
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 1
ER -