Overproduction of neutrophil radical oxygen species correlates with negative symptoms in schizophrenic patients: Parallel studies on neutrophil chemotaxis, superoxide production and bactericidal activity

Pinkhas Sirota, Ronit Gavrieli, Baruch Wolach

Research output: Contribution to journalArticlepeer-review

Abstract

Defective neutrophil function in schizophrenic patients has recently been reported. There are several lines of evidence to support the contribution of oxygen free radicals in schizophrenia, including increased lipid peroxidation, fatty acids and alterations in blood levels of anti-oxidant enzymes. Eighteen schizophrenic patients (DSM-IV) and 15 healthy controls were studied. Neutrophil chemotaxis, superoxide production and bactericidal activity were investigated. A statistically significant increase of superoxide anion release was found in schizophrenic patients compared with controls (mean±S.E.M., patients: 6.89±0.30 nmol O2-/106 cells/min, controls: 5.13±0.55 nmol O2-/10 6 cells/min). Moreover, a significant positive correlation between superoxide production and negative symptoms as assessed by the Positive and Negative Syndrome Scale was demonstrated. No differences were detected in chemotaxis and phagocytosis between schizophrenic patients and healthy controls. The present findings of a positive correlation between superoxide generation and negative symptoms in schizophrenic patients support the hypothesis that superoxide anion may participate in the pathogenesis of schizophrenia, as an excess of free radicals could contribute to the deterioration phase of the disease. Further studies are required to establish the role of oxidative stress in the ethiopathogenesis of schizophrenia.

Original languageEnglish
Pages (from-to)123-132
Number of pages10
JournalPsychiatry Research
Volume121
Issue number2
DOIs
StatePublished - 1 Dec 2003

Keywords

  • Chemotaxis
  • Free radicals
  • Phagocytosis
  • Reactive oxygen species
  • Schizophrenia
  • Superoxide anion

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