Overdose of Booster Tetanus Toxoid Given in Error: A Clinical Study

Izic Melamed; Yitzhak Romem; Tuvia Shimoni; Yosef Perek; Eran Dolev

doi:10.3109/inf.1983.15.issue-3.11

Overdose of Booster Tetanus Toxoid Given in Error: A Clinical Study

Izic Melamed, Yitzhak Romem, Tuvia Shimoni, Yosef Perek, Eran Dolev

Israel Defense Forces

Research output: Contribution to journal › Article › peer-review

Abstract

16 reserve soldiers received an overdose of tetanus toxoid vaccine (5 ml instead of 0.5 ml) in error. We assessed the incidence and severity of adverse reactions and determined tetanus antibody titer immediately and after 5 days, 1 month and 1 year, and compared it with the titers in a control group of 20 soldiers. The incidence and severity of reactions was significantly higher in the overdose group. The mean tetanus antibody titer rose to similar levels in both groups after 1 month (153.7582.5 IU/ml and 62.0242.15 IU/ml respectively) but decreased sharply after 1 year in the overdose group.

Original language	English
Pages (from-to)	303-306
Number of pages	4
Journal	Scandinavian Journal of Infectious Diseases
Volume	15
Issue number	3
DOIs	https://doi.org/10.3109/inf.1983.15.issue-3.11
State	Published - Sep 1983
Externally published	Yes

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10.3109/inf.1983.15.issue-3.11

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title = "Overdose of Booster Tetanus Toxoid Given in Error: A Clinical Study",

abstract = "16 reserve soldiers received an overdose of tetanus toxoid vaccine (5 ml instead of 0.5 ml) in error. We assessed the incidence and severity of adverse reactions and determined tetanus antibody titer immediately and after 5 days, 1 month and 1 year, and compared it with the titers in a control group of 20 soldiers. The incidence and severity of reactions was significantly higher in the overdose group. The mean tetanus antibody titer rose to similar levels in both groups after 1 month (153.7582.5 IU/ml and 62.0242.15 IU/ml respectively) but decreased sharply after 1 year in the overdose group.",

author = "Izic Melamed and Yitzhak Romem and Tuvia Shimoni and Yosef Perek and Eran Dolev",

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AU - Romem, Yitzhak

AU - Shimoni, Tuvia

AU - Perek, Yosef

AU - Dolev, Eran

PY - 1983/9

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N2 - 16 reserve soldiers received an overdose of tetanus toxoid vaccine (5 ml instead of 0.5 ml) in error. We assessed the incidence and severity of adverse reactions and determined tetanus antibody titer immediately and after 5 days, 1 month and 1 year, and compared it with the titers in a control group of 20 soldiers. The incidence and severity of reactions was significantly higher in the overdose group. The mean tetanus antibody titer rose to similar levels in both groups after 1 month (153.7582.5 IU/ml and 62.0242.15 IU/ml respectively) but decreased sharply after 1 year in the overdose group.

AB - 16 reserve soldiers received an overdose of tetanus toxoid vaccine (5 ml instead of 0.5 ml) in error. We assessed the incidence and severity of adverse reactions and determined tetanus antibody titer immediately and after 5 days, 1 month and 1 year, and compared it with the titers in a control group of 20 soldiers. The incidence and severity of reactions was significantly higher in the overdose group. The mean tetanus antibody titer rose to similar levels in both groups after 1 month (153.7582.5 IU/ml and 62.0242.15 IU/ml respectively) but decreased sharply after 1 year in the overdose group.

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JO - Scandinavian Journal of Infectious Diseases

JF - Scandinavian Journal of Infectious Diseases

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ER -

Overdose of Booster Tetanus Toxoid Given in Error: A Clinical Study

Abstract

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