Overcoming molecular mechanisms of resistance to first-generation epidermal growth factor receptor tyrosine kinase inhibitors

Jair Bar*, Amir Onn

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib have provided substantial benefits to patients with advanced non-small cell lung cancer (NSCLC). However resistance to these agents has emerged as a significant clinical issue; most patients who initially respond to treatment eventually experience relapse. The mechanisms underlying gefitinib and erlotinib resistance are multifactorial and several have been described. Clearly there is a need for novel and more effective therapies that can overcome resistance to the currently available TKIs. Several agents are in clinical development, including irreversible EGFR TKIs, inhibitors of the MET pathway, and others. In this review we discuss the various underlying mechanisms of gefitinib and erlotinib resistance and highlight the agents currently in clinical development that may have potential for overcoming this resistance.

Original languageEnglish
Pages (from-to)267-279
Number of pages13
JournalClinical Lung Cancer
Volume13
Issue number4
DOIs
StatePublished - Jul 2012
Externally publishedYes

Keywords

  • EGFR
  • Irreversible tyrosine kinase inhibitors
  • NSCLC
  • Resistance
  • Reversible tyrosine kinase inhibitors

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