@article{c230121571ee4cfebf55cca521e0c51b,
title = "Overcoming molecular mechanisms of resistance to first-generation epidermal growth factor receptor tyrosine kinase inhibitors",
abstract = "The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib have provided substantial benefits to patients with advanced non-small cell lung cancer (NSCLC). However resistance to these agents has emerged as a significant clinical issue; most patients who initially respond to treatment eventually experience relapse. The mechanisms underlying gefitinib and erlotinib resistance are multifactorial and several have been described. Clearly there is a need for novel and more effective therapies that can overcome resistance to the currently available TKIs. Several agents are in clinical development, including irreversible EGFR TKIs, inhibitors of the MET pathway, and others. In this review we discuss the various underlying mechanisms of gefitinib and erlotinib resistance and highlight the agents currently in clinical development that may have potential for overcoming this resistance.",
keywords = "EGFR, Irreversible tyrosine kinase inhibitors, NSCLC, Resistance, Reversible tyrosine kinase inhibitors",
author = "Jair Bar and Amir Onn",
note = "Funding Information: This work was supported by Boehringer Ingelheim Pharmaceuticals, Inc (BIPI). Editorial assistance was provided by Staci Heise, PhD, of MedErgy, which was contracted by BIPI for these services. The authors meet criteria for authorship as recommended by the International Committee of Medical Journal Editors (ICMJE), were fully responsible for all content and editorial decisions, and were involved at all stages of manuscript development. The authors received no compensation related to the development of the manuscript. The authors would like to acknowledge Roy Herbst, MD, PhD, for his insightful comments and careful review.",
year = "2012",
month = jul,
doi = "10.1016/j.cllc.2011.09.001",
language = "אנגלית",
volume = "13",
pages = "267--279",
journal = "Clinical Lung Cancer",
issn = "1525-7304",
publisher = "Elsevier Inc.",
number = "4",
}
