Ovarian cyst formation in two pre-menopausal patients treated with tamoxifen for breast cancer

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Abstract

Pre-menopausal tamoxifen treatment causes hyperoestrogen production and ovarian cyst formation. Two pre-menopausal breast cancer patients who were treated with tamoxifen developed both permanent supraphysiological oestrogen concentration and ovarian cysts. Serum oestrogen decreased to post-menopausal concentrations and ovarian cysts completely resolved during and following simultaneous treatment with tamoxifen and gonadotrophin-releasing hormone agonist (GnRHa). In pre-menopausal breast cancer patients, GnRHa may prevent possible side-effects of tamoxifen, such as ovarian cysts and supraphysiological oestrogen production.

Original languageEnglish
Pages (from-to)1427-1429
Number of pages3
JournalHuman Reproduction
Volume9
Issue number8
DOIs
StatePublished - Aug 1994
Externally publishedYes

Keywords

  • Breast cancer
  • GnRH
  • Oestrogens
  • Pre-menopause
  • Tamoxifen

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