TY - JOUR
T1 - Ovarian cancer and high-risk women - Implications for prevention, screening, and early detection
AU - Modugno, Francesmary
AU - Boyd, Jeff
AU - Baum, Andrew
AU - Bigbee, William L.
AU - Cramer, Daniel
AU - Ferrell, Robert
AU - Gallion, Holly H.
AU - Greene, Mark H.
AU - Goldman, Patricia
AU - Johnson, Karen A.
AU - Junker, Barbara
AU - Kuller, Lewis
AU - Kurman, Robert J.
AU - Maihle, Nita
AU - Narod, Steven
AU - Ness, Roberta B.
AU - Risch, Harvey
AU - Rodriguez, Gustavo
AU - Sadetzki, Siegal
AU - Skates, Steven
AU - Stein, Maxine
AU - Weissfeld, Joel L.
N1 - Funding Information:
Support for the Ovarian Cancer and High-Risk Women: Implications of Prevention, Screening and Early Detection symposium held in Pittsburgh, Pennsylvania, May 2002 was provided by the Pennsylvania Department of Health (ME 01294), the National Cancer Institute, Division of Cancer Prevention (1R13CA096933-01) and Office of Women's Health, and grants from the Scaife Family Foundation, the Jewish Healthcare Foundation, and the Ladies Hospital Aid Society of Western Pennsylvania. Additional funds for this work were provided by NCI K07-CA80668 (F. Modugno). We thank Randi Koenig for helping to prepare the manuscript. We further thank Dr. Jeffrey L. Eppinger for his support of this work. We also thank the anonymous reviewers whose comments improved the presentation of the manuscript. This article is dedicated to the memories of Baruch Modan, M.D., Karen F. Bowers, and Barbara Junker, whose lives were each touched by ovarian cancer and whose courage and dedication to overcoming this disease continue to inspire us.
PY - 2003/10/1
Y1 - 2003/10/1
N2 - Objectives. The aim of this study was to understand the strengths and limitations of current prevention, detection, and screening methods for ovarian cancer and to identify research areas to improve prevention, screening, and detection of the disease for all women as well as for women carrying a mutation in the BRCA1/2 genes. Methods. We convened an ovarian cancer symposium at the University of Pittsburgh in May 2002. Nineteen leading scientists representing disciplines such as epidemiology, molecular biology, pathology, genetics, bioinformatics, and psychology presented the latest data on ovarian cancer prevention, screening, and early detection. Results. Ovarian cancer is the most common cause of death from a gynecologic malignancy in the United States. Because survival depends on stage of diagnosis, early detection is critical in improving clinical outcome. However, existing screening techniques (CA125, transvaginal ultrasound) have not been shown to reduce morbidity or mortality. Moreover, with the exception of oral contraceptives, there are no available chemopreventive agents. Bilateral salpingo-oophorectomy also has been shown to reduce incidence, but this procedure has several drawbacks in terms of a woman's reproductive, cardiovascular, skeletal, and mental health. Conclusion. Better methods to prevent, detect, and screen for ovarian cancer in all women, but particularly in high-risk women carrying mutations in BRCA1/2, are urgently needed. This article reviews the current state of knowledge in the etiology, prevention, and early detection of ovarian cancer and suggests several areas for future clinical, epidemiologic, and laboratory-based research.
AB - Objectives. The aim of this study was to understand the strengths and limitations of current prevention, detection, and screening methods for ovarian cancer and to identify research areas to improve prevention, screening, and detection of the disease for all women as well as for women carrying a mutation in the BRCA1/2 genes. Methods. We convened an ovarian cancer symposium at the University of Pittsburgh in May 2002. Nineteen leading scientists representing disciplines such as epidemiology, molecular biology, pathology, genetics, bioinformatics, and psychology presented the latest data on ovarian cancer prevention, screening, and early detection. Results. Ovarian cancer is the most common cause of death from a gynecologic malignancy in the United States. Because survival depends on stage of diagnosis, early detection is critical in improving clinical outcome. However, existing screening techniques (CA125, transvaginal ultrasound) have not been shown to reduce morbidity or mortality. Moreover, with the exception of oral contraceptives, there are no available chemopreventive agents. Bilateral salpingo-oophorectomy also has been shown to reduce incidence, but this procedure has several drawbacks in terms of a woman's reproductive, cardiovascular, skeletal, and mental health. Conclusion. Better methods to prevent, detect, and screen for ovarian cancer in all women, but particularly in high-risk women carrying mutations in BRCA1/2, are urgently needed. This article reviews the current state of knowledge in the etiology, prevention, and early detection of ovarian cancer and suggests several areas for future clinical, epidemiologic, and laboratory-based research.
UR - http://www.scopus.com/inward/record.url?scp=0141817892&partnerID=8YFLogxK
U2 - 10.1016/S0090-8258(03)00254-3
DO - 10.1016/S0090-8258(03)00254-3
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C2 - 14529658
AN - SCOPUS:0141817892
SN - 0090-8258
VL - 91
SP - 15
EP - 31
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 1
ER -
